COVID-19 could leave measurable traces in the brain

COVID-19 could leave measurable traces in the brain

COVID-19 not only affects the respiratory system, but also significantly alters the brains of people who have fully recovered from the infectious disease, highlighting the long-term neurological effects of the virus.

Researchers at Griffith University's National Center for Neuroimmunology and Emerging Disease (NCNED) used advanced MRI techniques to determine the neurological impact of COVID-19 compared to those who have never been infected.

The research provided convincing evidence that previous infection with the virus can leave a measurable imprint on the brain, even without persistent symptoms.

We used multimodal MRI techniques to examine both gray and white matter brain regions critical for memory, cognition and overall brain health and found significant differences between all participant groups.

The unique MRI approach identified significant changes in brain neurochemicals, brain signal intensity and tissue structure not only in people with long-COVID, but also in people who considered themselves fully recovered.

The study also found that altered brain tissue was associated with symptom severity in people with long COVID, suggesting the virus may leave a silent, lasting effect on brain health.”

Dr. Kiran Thapaliya, lead author

These results provide important insights into the effects of COVID-19 on the central nervous system and may help explain the cognitive problems such as memory and concentration reported both shortly after infection and months or even years later.

NCNED Director Professor Sonya Marshall-Gradisnik said: “NCNED brings together a critical mass of talented researchers and clinicians committed to improving patients’ lives.”

“We have the privilege of access to cutting-edge technologies that drive transformative scientific discoveries.”

The research was funded by ME Research UK and the Stafford Fox Medical Research Foundation.

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