Naloxegol

Naloxegol

Naloxegol

What is Naloxegol?

Naloxegol is used to treat chronic pain not caused by cancer in patients who have been taking opioid pain medications for at least 4 weeks.

Naloxegol may also be used for purposes not listed in this medication guide.

Naloxegol side effects

If necessary, get emergency medical helpSigns of an allergic reaction: hives; difficult breathing; Swelling of your face, lips, tongue, or throat.

Naloxegol can cause serious side effects. Call your doctor immediately if you have:

• Symptoms of opioid withdrawal: anxiety, irritability, sweating, chills, yawning, stomach pain, diarrhea.

Stop taking naloxegol and call your doctor immediately if you have:

• severe stomach pain that doesn't go away; or

• severe diarrhea.

Common side effects of naloxegol may include:

• nausea, vomiting, stomach pain;

• diarrhea, flatulence; or

• Headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use naloxegol if your stomach or intestines are blocked.

Tell your doctor if you have symptoms of opioid withdrawal, such as: B. Anxiety, irritability, sweating, chills, yawning, stomach pain and diarrhea.

Stop using naloxegol and call your doctor immediately if you have severe stomach pain and/or diarrhea (which may lead to serious medical problems).

Tell your doctor about all medications you are currently taking and any medications you are taking or stopping. Many medicines can interact, and some medicines should not be used together.

Before you take this medicine

You should not use naloxegol if you are allergic to it or if you have:

• a blockage in your stomach or intestines.

Some medicines may cause unwanted or dangerous effects when used at the same time as naloxegol. Your doctor may need to change your treatment plan if you are also taking:

• certain antibiotics;

• antifungal;

• heart medications; or

• antiviral medicine used to treat hepatitis C or HIV.

Tell your doctor if you have ever had:

• stomach or intestinal problems (including diverticulitis or ischemic colitis);

• stomach cancer, colon cancer;

• a perforation (a hole or tear) in your esophagus, stomach or intestines;

• recent surgery on the stomach or intestines; or

• Liver or kidney disease.

If you use naloxegol during pregnancy, your baby may experience opioid withdrawal symptoms.Tell your doctor if you are pregnant or planning to become pregnant.

Do not breast-feed while taking naloxegol.

Naloxegol is not approved for use by people under 18 years of age.

How should I take naloxegol?

Follow all instructions on your prescription label and read any medication guides or instructions for use. Use the medicine exactly as directed.

Take naloxegol on an empty stomach, at least 1 hour before or 2 hours after your first meal of the day.

If you cannot swallow a naloxegol tablet whole, you can crush the tablet into a powder and mix it with 4 ounces of water. Stir and drink this mixture immediately. To get the full dose, add a little more water to the same glass, swirl gently, and drink immediately.

Naloxegol can also be administered through a nasogastric tube. Carefully read and follow all instructions for use that come with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Call your doctor if your symptoms do not improve after 3 days of treatment.

After you stop taking your painkillers, you should also stop taking naloxegol.

Store at room temperature, protected from moisture and heat.

Naloxegol dosage information

Usual adult dose for constipation – medication-related:

Opioid-induced constipation – chronic:

Initial dose: 25 mg orally once daily
Maintenance dose: 25 mg orally once daily; In patients unable to tolerate a higher dose, the dose may be reduced to 12.5 mg orally once daily

Comments: Discontinue any maintenance treatment with laxatives before beginning; If the response after 3 days is suboptimal, laxatives can be used as needed.

Use: For the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain.

What happens if I miss a dose?

Take the medicine as soon as possible, but skip the missed dose if it is almost time for the next dose. Do not take two doses at the same time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help hotline at 1-800-222-1222.

What should I avoid while taking naloxegol?

Do not use any other laxatives that your doctor has not prescribed.

Grapefruit may interact with naloxegol and cause unwanted side effects. Avoid using grapefruit products.

What other drugs will affect naloxegol?

Sometimes it is not safe to take certain medications at the same time. Some medications can affect the blood levels of other medications you are taking, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially bevacizumab.

This list is not complete. Other medications can affect naloxegol, including prescription and over-the-counter medications, vitamins, and herbal products. Not all possible drug interactions are listed here.

More information

Remember to keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the prescribed indication.