Verapamil (oral)

Verapamil (oral)

Uses for Verapamil

Verapamil is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, verapamil relaxes the blood vessels, increasing the blood and oxygen supply to the heart while reducing its workload.

This medicine is only available with a doctor's prescription.

Before using verapamil

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

No appropriate studies have been conducted on the relationship between age and the effects of verapamil in children and adolescents. Safety and effectiveness have not been established.

geriatrics

Studies conducted to date have not shown any geriatric-specific problems that would limit the benefit of verapamil in older people. However, older patients are at higher risk of age-related heart, liver, or kidney problems, which may require dosage adjustments in patients receiving verapamil.

Breastfeeding

There are insufficient studies in women to determine the risk to infants when using this drug while breast-feeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are taking this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or to change some of the other medications you are taking.

• Colchicin
• Dofetilid
• Eliglustat
• Flibanserin
• Lomitapid

Using this medicine with any of the following medicines is not usually recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Abametapir
• Acalabrutinib
• Acebutolol
• Adenosin
• Afatinib
• Alfentanil
• Alprazolam
• Amiodaron
• Apixaban
• Aprepitant
• Atazanavir
• Atenolol
• Atorvastatin
• Avapritinib
• Benzhydrocodon
• Berotralstat
• Betaxolol
• Betrixaban
• Bisoprolol
• Bosutinib
• Brexpiprazol
• Brigatinib
• Bupivacain
• Bupivacain-Liposom
• Buprenorphin
• Carbamazepin
• Carteolol
• Carvedilol
• Celiprolol
• Ceritinib
• Cilostazol
• Clarithromycin
• Clonidin
• Clopidogrel
• Clozapin
• Cobicistat
• Cobimetinib
• Kodein
• Conivaptan
• Cyclobenzaprin
• Dabigatranetexilat
• Dantrolen
• Daridorexant
• Darunavir
• Deflazacort
• Digoxin
• Dihydrocodein
• Domperidon
• Doxorubicin
• Doxorubicin-Hydrochlorid-Liposom
• Dronedaron
• Edoxaban
• Elastan
• Elexacaftor
• Encorafenib
• Entrectinib
• Epirubicin
• Eplerenon
• Erythromycin
• Esmolol
• Everolimus
• Fedratinib
• Fentanyl
• Fexinidazol
• Finerenon
• Fingolimod
• Fluconazol
• Fosaprepitant
• Fosnetupitant
• Gepiron
• Hydrocodon
• Ibrutinib
• Ifosfamid
• Infigratinib
• Itraconazol
• Ivabradin
• Ivacaftor
• Ivosidenib
• Ketoconazol
• Labetalol
• Lacosamid
• Larotrectinib
• Lefamulin
• Lemborexant
• Levobunolol
• Lovastatin
• Lumateperon
• Lurasidon
• Lurbinectedin
• Mavacamten
• Melphalan
• Meperidin
• Mepivacain
• Methadon
• Metipranolol
• Metoprolol
• Mitapivat
• Mobocertinib
• Morphium
• Morphinsulfat-Liposom
• Nadolol
• Naloxegol
• Nebivolol
• Neratinib
• Netupitant
• Nilotinib
• Olaparib
• Omaveloxolon
• Oxprenolol
• Oxycodon
• Pacritinib
• Palbociclib
• Palovaroten
• Pemigatinib
• Penbutolol
• Pentazocin
• Pexidartinib
• Phenobarbital
• Pindolol
• Piperaquin
• Pixantrone
• Ponesimod
• Pralsetinib
• Primidon
• Propranolol
• Ranolazin
• Relugolix
• Rimegepant
• Rivaroxaban
• Selpercatinib
• Selumetinib
• Simeprevir
• Simvastatin
• Siponimod
• Sirolimus
• Proteingebundenes Sirolimus
• Sonidegib
• Sotalol
• Sparsentan
• Sufentanil
• Tacrolimus
• Talazoparib
• Tazemetostat
• Temsirolimus
• Tenofoviralafenamid
• Tezacaftor
• Timolol
• Tizanidin
• Tolvaptan
• Topotecan
• Tramadol
• Ubrogepant
• Venetoclax
• Venlafaxin
• Vincristin
• Vincristinsulfat-Liposom
• Voclosporin
• Zanubrutinib
• Zolpidem

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Amlodipin
• Buspiron
• Cyclosporin
• Dalfopristin
• Digitoxin
• Dutasterid
• Flecainid
• Fosphenytoin
• Indinavir
• Lithium
• Metformin
• Midazolam
• Nevirapin
• Oxcarbazepin
• Pancuronium
• Phenytoin
• Chinidin
• Quinupristin
• Rifapentin
• Johanniskraut
• Suvorexant
• Tedisamil
• Telithromycin
• Tubocurarin
• Vecuronium

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine for any of the following conditions is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or frequency of use of this medication, or give you special instructions about food, alcohol, or tobacco consumption.

• Tabak

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but may be unavoidable in some cases. If used together, your doctor may change the dose or frequency of use of this medication, or give you special instructions about food, alcohol, or tobacco consumption.

• Ethanol
• Grapefruitsaft

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Herzinsuffizienz oder
• Muskelerkrankungen (z. B. Duchenne-Muskeldystrophie, Myasthenia gravis) oder
• Lungenödem (Flüssigkeit in der Lunge) – Mit Vorsicht anwenden. Kann diese Bedingungen verschlimmern.

• Herzblock (Art von Herzrhythmusstörung) oder
• Herzprobleme (z. B. Wolff-Parkinson-White-Syndrom, Lown-Ganong-Levine-Syndrom) oder
• Niedriger Blutdruck (Hypotonie) oder
• Sick-Sinus-Syndrom (Herzrhythmusstörung, kann verwendet werden, wenn Sie einen ordnungsgemäß funktionierenden Herzschrittmacher haben) – Sollte bei Patienten mit diesen Erkrankungen nicht angewendet werden.

• Nierenprobleme bzw
• Leberprobleme – Mit Vorsicht anwenden. Die Wirkung kann durch die langsamere Entfernung des Arzneimittels aus dem Körper verstärkt werden.

Correct use of verapamil

In addition to using this medicine, treating your high blood pressure may include controlling your weight and changing the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. Before changing your diet, you should consult your doctor.

Many patients with high blood pressure don't notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and keep your appointments with your doctor, even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it will help control it. If you expect your blood pressure to decrease and decrease, you must continue taking it as directed. You may need to take medication for high blood pressure for the rest of your life. If left untreated, high blood pressure can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet whole with a full glass of water. Do not break, crush or chew it. It is best to take this medicine with food.

If you cannot swallow the verapamil extended-release capsules, you can open them and sprinkle the pellets contained in the capsule on a tablespoon of applesauce. This mixture must be swallowed immediately with a glass of cold water. The applesauce should not be hot and soft enough to be swallowed without chewing. Do not chew or crush the pellets.

If you are taking extended-release tablets, you may sometimes notice something that looks like a tablet in your stool. This is the empty tablet shell that remains after the medicine has been absorbed.

dosage

The dose of this medicine is different for different patients. Follow your doctor's instructions or the label directions. The following information includes average doses of this medicine only. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. In addition, the number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical problem for which you are using the medicine.

• Bei Brustschmerzen:
  • Für orale Darreichungsform (Tabletten):
    • Erwachsene – Die übliche Dosis beträgt 80 bis 120 Milligramm (mg) dreimal täglich. Ihr Arzt kann Ihre Dosis bei Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
  • Für die orale Darreichungsform (Retardtabletten, 24 Stunden):
    • Erwachsene – zunächst 180 Milligramm (mg) einmal täglich vor dem Schlafengehen. Ihr Arzt kann Ihre Dosis bei Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
• Bei Herzrhythmusstörungen:
  • Für orale Darreichungsform (Tabletten):
    • Erwachsene – Die übliche Gesamtdosis beträgt 240 bis 480 Milligramm (mg), aufgeteilt in drei oder vier gleiche Dosen pro Tag.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
• Bei Bluthochdruck:
  • Für orale Darreichungsform (Tabletten):
    • Erwachsene – zunächst 80 Milligramm (mg) dreimal täglich. Ihr Arzt kann Ihre Dosis bei Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
  • Für die orale Darreichungsform (Retardkapseln):
    • Erwachsene – zunächst 200 Milligramm (mg) einmal täglich vor dem Schlafengehen. Ihr Arzt kann Ihre Dosis bei Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
  • Für die orale Darreichungsform (Retardtabletten):
    • Erwachsene – zunächst 180 Milligramm (mg) einmal täglich morgens. Ihr Arzt kann Ihre Dosis bei Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
  • Für die orale Darreichungsform (Retardtabletten, 24 Stunden):
    • Erwachsene – zunächst 180 Milligramm (mg) einmal täglich vor dem Schlafengehen. Ihr Arzt kann Ihre Dosis bei Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Protect from freezing.

Keep away from children.

Do not keep medications that are outdated or no longer needed.

Ask your doctor how to throw away medicines you don't use.

Precautions when using verapamil

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for any unwanted effects.

Low blood pressure (hypotension) may occur while taking this medication. Contact your doctor immediately if you experience the following symptoms: blurred vision; Confusion; severe dizziness, fainting or lightheadedness when standing up suddenly from a lying or sitting position; Sweat; or unusual tiredness or weakness.

While taking this medication, be sure to limit the amount of alcohol you drink. Alcohol increases dizziness and sleepiness and also lowers blood pressure.

Verapamil side effects

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Consult your doctor immediately if any of the following side effects occur:

Less common

• Blaue Lippen und Fingernägel
• verschwommene Sicht
• Brennen, Krabbeln, Jucken, Taubheitsgefühl, Kribbeln, Kribbeln oder Kribbeln
• Brustschmerzen
• Verwirrung
• Husten, der manchmal einen rosafarbenen, schaumigen Auswurf erzeugt
• schwieriges, schnelles, lautes Atmen, manchmal mit pfeifender Atmung
• Schwindel, Ohnmacht oder Benommenheit beim plötzlichen Aufstehen aus einer liegenden oder sitzenden Position
• vermehrtes Schwitzen
• Benommenheit, Schwindel oder Ohnmacht
• blasse Haut
• Kurzatmigkeit
• langsamer oder unregelmäßiger Herzschlag
• Halsentzündung
• Schwitzen
• Schwellungen in Beinen und Knöcheln
• ungewöhnliche Müdigkeit oder Schwäche

Rarely

• Schüttelfrost
• kalter Schweiß
• Gefühl von Wärme
• Rötung des Gesichts, des Halses, der Arme und gelegentlich der oberen Brust

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Schwierigkeiten beim Stuhlgang (Stuhl)
• Kopfschmerzen

Less common

• Saurer oder saurer Magen
• Aufstoßen
• Schwierigkeiten beim Bewegen
• Sodbrennen
• Verdauungsstörungen
• Gelenkschmerzen
• Muskelschmerzen oder Krämpfe
• Muskelschmerzen oder Steifheit
• Brechreiz
• Ausschlag
• Magenbeschwerden, Magenverstimmung oder Schmerzen
• Schlafstörungen
• ungewöhnliche Schläfrigkeit, Mattheit, Müdigkeit, Schwäche oder Trägheitsgefühl
• geschwollene Gelenke

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Calan
• Calan SR
• Covera-HS
• Isoptin SR
• Verelan
• Verelan PM

Available dosage forms:

• Tablette
• Tablet, erweiterte Version
• Kapsel, verlängerte Veröffentlichung

Therapeutic class: cardiovascular agents

Pharmacological class: Calcium channel blockers

Chemical Class: Phenylalkylamine

More information