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Researchers develop new bandage treatment to treat diabetic foot ulcers
Researchers at Queen's University Belfast have developed a new dressing treatment, called a scaffold, to treat diabetic foot ulcers that is cost-effective while improving patient outcomes. The 3D bioprinted scaffolds slowly release antibiotics over a period of four weeks to effectively treat the wound. Diabetes, a lifelong disease that causes high blood sugar levels, is one of the top ten causes of death worldwide. Diabetic foot ulcer (DFU) is a serious complication of diabetes and affects approximately 25% of diabetics. When identified, over 50% are already infected and over 70% of cases...
Researchers develop new bandage treatment to treat diabetic foot ulcers
Researchers at Queen's University Belfast have developed a new dressing treatment, called a scaffold, to treat diabetic foot ulcers that is cost-effective while improving patient outcomes. The 3D bioprinted scaffolds slowly release antibiotics over a period of four weeks to effectively treat the wound.
Diabetes, a lifelong disease that causes high blood sugar levels, is one of the top ten causes of death worldwide.
Diabetic foot ulcer (DFU) is a serious complication of diabetes and affects approximately 25% of diabetics. When identified, over 50% are already infected and over 70% of cases result in lower limb amputation.
The treatment strategy required for the effective cure of DFU is a complex process that requires multiple combined therapeutic approaches. Therefore, the treatment of DFU is associated with a significant clinical and economic burden. These treatments are often unsuccessful, resulting in amputation of the lower limbs.
This new research shows results with significant impact on patients' quality of life as well as a reduction in the cost and clinical burden of treating DFU.
Recent research has focused on drug-loaded scaffolds to treat DFU. The scaffold structure is a novel carrier for cell and drug delivery that improves wound healing.
The research, published in Springer Link, will be presented by Professor Lamprou at the Controlled Release Society (CRS) Italy workshop (October 7-9).
Professor Dimitrios Lamprou, Professor of Biofabrication and Advanced Manufacturing at the Queen's School of Pharmacy and corresponding author, explains: "These scaffolds are like windows that allow doctors to constantly monitor healing. This avoids the need to constantly remove them, which can lead to infections." delay the healing process.
"The 'frame' contains an antibiotic that helps kill the bacterial infection, and the 'glass', which can be made from collagen/sodium alginate, can contain a growth factor that promotes cell growth. The framework is made up of two molecular layers that do both." play an important role in wound healing.”
Using bioprinting technology, we developed a scaffold with suitable mechanical properties for wound treatment that can be easily adjusted to the size of the wound. This represents a cost-effective alternative to current DFU treatments that could revolutionize DFU treatment, improving patient outcomes while reducing the economic burden created by rapidly increasing patient demand as the number of people with diabetes continues to increase each year.”
Ms Katie Glover, lead author, Queen’s School of Pharmacy
Source:
Reference:
Glover, K., et al. (2022) 3D bioprinted scaffolds for diabetic wound healing applications. Drug delivery and translational research. doi.org/10.1007/s13346-022-01115-8.
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