Suche
Mein Konto
Study describes risk factors for people with chronic pancreatitis to develop diabetes
A new study from Cedars-Sinai researchers describes risk factors that may make people with chronic pancreatitis, a persistent inflammation of the pancreas, more likely to develop diabetes. The results are published in Diabetes Care. Some of these risk factors include smoking and being overweight. “We hope to use this information to create predictive models that clinicians can use to treat patients with chronic pancreatitis who do not already have diabetes,” said Mark Goodarzi, MD, PhD, the Eris M. Field Chair in Diabetes Research at Cedars-Sinai and senior author of the study. "We can look at these factors and say, 'This patient is at high risk of...
Study describes risk factors for people with chronic pancreatitis to develop diabetes
A new study from Cedars-Sinai researchers describes risk factors that may make people with chronic pancreatitis, a persistent inflammation of the pancreas, more likely to develop diabetes. The results are published in Diabetes Care.
Some of these risk factors include smoking and being overweight.
“We hope to use this information to create predictive models that clinicians can use to treat patients with chronic pancreatitis who do not already have diabetes,” said Mark Goodarzi, MD, PhD, the Eris M. Field Chair in Diabetes Research at Cedars-Sinai and senior author of the study. “We can look at these factors and say, ‘This patient is at high risk of developing diabetes within X years,’ which allows us to identify patients who we need to monitor closely to prevent diabetes.”
According to the National Pancreas Foundation, in industrialized nations such as the United States, about 5 to 12 people out of 100,000 develop chronic pancreatitis. When the pancreas experiences chronic inflammation, it can become damaged, preventing the organ from helping the body digest food. Many studies show that most people with chronic pancreatitis will eventually develop diabetes.
For this study, researchers collected information from 645 people with chronic pancreatitis who participated in a study called Prospective Evaluation of Chronic Pancreatitis for Epidemiological and Translational Studies (PROCEED). Of the people participating in PROCEED, 276 had diabetes. Their ages ranged from 18 to 75 years. Researchers compared factors known to increase the risk of type 2 diabetes, such as tobacco and alcohol consumption, after they were diagnosed with chronic pancreatitis. They found that:
- Bei Männern war die Wahrscheinlichkeit, an Diabetes zu erkranken, mehr als doppelt so hoch (2,42) wie bei Frauen.
- Menschen, die übergewichtig oder fettleibig waren, hatten ein fast dreimal (2,76) höheres Risiko, an Diabetes zu erkranken als Menschen mit normalem Gewicht.
- Menschen, die sich als nicht weiß identifizierten, entwickelten mit mehr als doppelt so hoher Wahrscheinlichkeit (2,33-2,53) Diabetes als diejenigen, die sich als weiß identifizierten.
- Bei Rauchern war die Wahrscheinlichkeit, an Diabetes zu erkranken, mehr als doppelt so hoch (2,08) wie bei Nichtrauchern.
- Ältere Menschen entwickelten eher Diabetes; Die Wahrscheinlichkeit, an der Krankheit zu erkranken, stieg um 3 % pro Lebensjahr.
Genetics & Genomics eBook
Compilation of the top interviews, articles and news from the last year. Download a free copy
The characteristics of a person's pancreatic disease, including a condition called exocrine pancreatic dysfunction, also contributed to the individual's risk factors.
“Known risk factors for type 2 diabetes, as well as pancreas-specific features such as calcium deposits in the pancreas or shrinkage of the pancreas, predicted who developed diabetes in people with pancreatitis,” said Christie Jeon, ScD, research associate in the Department of Medicine, research scientist at the Samuel Oschin Cancer Institute at Cedars-Sinai and first author of the study.
For some people, it may be possible to change behaviors associated with diabetes risk.
Models that predict diabetes risk could encourage clinicians to connect patients with weight loss or smoking cessation programs.”
Mark Goodarzi, MD, PhD, director of the Division of Endocrinology, Diabetes and Metabolism at Cedars-Sinai
Researchers are currently following a larger group of patients to see if the same risk factors uncovered in this study predict who will develop diabetes in this population. Future studies will analyze how genetics and insulin and hormone levels may predispose people with chronic pancreatitis to diabetes risk, the authors said.
Eleanor Chang, clinical research coordinator at Cedars-Sinai, also worked on the study.
Source:
Reference:
Jeon, C., et al. (2022) Development of a Clinical Prediction Model for Diabetes in Chronic Pancreatitis: The PREDICT3c Study. Diabetes treatment. doi.org/10.2337/dc22-1414.
.