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Study Finds Geographical Differences in PCOS Symptoms Among Black and White Women
Women with polycystic ovary syndrome (PCOS) in Alabama may be at higher risk of excessive hair growth and insulin resistance, while women with PCOS in California may be more likely to have higher testosterone levels, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism. PCOS affects 7-10% of women of childbearing age and is the most common cause of infertility. An estimated 5 to 6 million women in the United States suffer from PCOS, but the condition is still underdiagnosed. In women, PCOS is diagnosed when two of the following criteria are present: Androgen excess (excess male sex hormones such as...
Study Finds Geographical Differences in PCOS Symptoms Among Black and White Women
Women with polycystic ovary syndrome (PCOS) in Alabama may be at higher risk of excessive hair growth and insulin resistance, while women with PCOS in California may be more likely to have higher testosterone levels, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism.
PCOS affects 7-10% of women of childbearing age and is the most common cause of infertility. An estimated 5 to 6 million women in the United States suffer from PCOS, but the condition is still underdiagnosed. In women, PCOS is diagnosed when two of the following criteria are present: androgen excess (excess male sex hormones such as testosterone), ovulation disorder, and polycystic ovaries.
Our study found geographic differences in PCOS in black and white women, suggesting that there are both genetic and environmental influences on the manifestation of this disease. Continued research is needed to identify modifiable risk factors for PCOS that may be race- and ethnic-specific in order to integrate precision medicine into the treatment of this disease.”
Margareta D. Pisarska, MD, Cedars-Sinai Medical Center in Los Angeles, California
Researchers compared data from 1,620 white and black women with PCOS in Alabama and California. They found regional differences in the way these women met criteria for a PCOS diagnosis and in the symptoms associated with PCOS, with some differences between black and white women.
Overall, there were many similarities between the breeds. Women with PCOS in Alabama were more likely to have excessive hair growth and insulin resistance, while women with PCOS in California were more likely to have higher testosterone levels.
When comparing black women with PCOS in Alabama and California, the average body mass index (BMI) did not differ between sites, whereas for white women with PCOS, the average BMI was higher in Alabama than in California.
“Now that we have established that there are geoepidemiological differences, we intend to conduct follow-up studies comparing black and white women with PCOS, taking geoepidemiological differences into account,” Pisarska said. “In addition, we seek to examine the factors that contribute to these differences in order to tailor treatments to specific needs and improve care for all women with PCOS.”
Additional authors of this study include Katherine VanHise, Jessica L. Chan, Sahar Wertheimer, Roy G. Handelsman, Ekaterina Clark, Rae Buttle and Erica T. Wang of Cedars-Sinai Medical Center; and Ricardo Azziz from the University of Alabama at Birmingham in Birmingham, Alabama and the University of Albany, SUNY, in Albany, NY
The study was funded by the National Institutes of Health and Helping Hand of Los Angeles, Inc.
Source:
Reference:
VanHise, K., et al. (2022) Regional variation in hormonal and metabolic parameters of white and black women with PCOS in the United States. Journal of Clinical Endocrinology and Metabolism. doi.org/10.1210/clinem/dgac515.
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