Genetic test to tell if your hip surgery will fail: Saliva swab could predict whether you will have an adverse reaction to a joint implant

Daniel Wom

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Veröffentlicht am 26.06.2022 und aktualisiert am 02.05.2024

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About 15% of Brits have genetic traits that cause the immune system to attack tissue around the material in joint implants, causing pain and swelling Studies have long shown that about a fifth of people react badly to an artificial joint made from cobalt chromium Until now, experts didn't know why, meaning doctors couldn't tell whether or not a patient would react badly to their new joint Saliva swab before your hip replacement could predict whether the procedure will work. British researchers have found that DNA signals lurking in saliva and blood samples are linked to an adverse reaction to materials in most joint implants...

Etwa 15 % der Briten haben genetische Merkmale, die das Immunsystem dazu bringen, Gewebe um das Material in Gelenkimplantaten anzugreifen, was Schmerzen und Schwellungen verursacht Studien belegen seit langem, dass etwa ein Fünftel der Menschen auf ein künstliches Gelenk aus Kobalt-Chrom schlecht reagiert Bisher wussten Experten nicht warum, was bedeutete, dass Ärzte nicht sagen konnten, ob ein Patient schlecht auf sein neues Gelenk reagieren würde oder nicht Ein Speichelabstrich vor Ihrem Hüftgelenkersatz könnte vorhersagen, ob das Verfahren funktioniert. Britische Forscher haben herausgefunden, dass DNA-Signale, die in Speichel- und Blutproben lauern, mit einer nachteiligen Reaktion auf Materialien in den meisten Gelenkimplantaten … — About 15% of Brits have genetic traits that cause the immune system to attack tissue around the material in joint implants, causing pain and swelling Studies have long shown that about a fifth of people react badly to an artificial joint made from cobalt chromium Until now, experts didn't know why, meaning doctors couldn't tell whether or not a patient would react badly to their new joint Saliva swab before your hip replacement could predict whether the procedure will work. British researchers have found that DNA signals lurking in saliva and blood samples are linked to an adverse reaction to materials in most joint implants...

Etwa 15 % der Briten haben genetische Merkmale, die das Immunsystem dazu bringen, Gewebe um das Material in Gelenkimplantaten anzugreifen, was Schmerzen und Schwellungen verursacht
Studien belegen seit langem, dass etwa ein Fünftel der Menschen auf ein künstliches Gelenk aus Kobalt-Chrom schlecht reagiert
Bisher wussten Experten nicht warum, was bedeutete, dass Ärzte nicht sagen konnten, ob ein Patient schlecht auf sein neues Gelenk reagieren würde oder nicht

A saliva swab before your hip replacement could predict whether the procedure will work.

British researchers have found that DNA signals lurking in saliva and blood samples are linked to an adverse reaction to materials in most joint implants.

Around 15 percent of Brits have these genetic traits, which cause the immune system to attack tissue around the material, causing pain and swelling.

Studies have long shown that around a fifth of people react badly to an artificial joint made of cobalt-chrome. But until now, experts didn't know why, meaning doctors couldn't tell whether or not a patient would react badly to their new joint.

British researchers have found that DNA signals lurking in saliva and blood samples are linked to an adverse reaction to materials in most joint implants. Around 15% of Brits have these genetic traits, which cause the immune system to attack tissue around the material, causing pain and swelling

In addition to discovering the genetic culprit, the Newcastle University research team has developed a testing system that can screen patients for the gene with about 90 percent accuracy.

In one study, more than 600 patients who had undergone joint replacement surgery in the last decade were tested with saliva swabs and blood tests.

A computer analyzed the data and revealed that the patients who experienced complications carried certain genes. The team believes they can use this testing system to identify who may be at risk.

Around ten percent of Brits will have joint replacement surgery during their lifetime. The procedure is often used to repair damage associated with arthritis or age-related wear and tear.

If the joint replacement is successful, it will last between 15 and 25 years.

For patients with a genetic sensitivity to cobalt-chromium, a second procedure using alternative materials is usually performed within months of the first.

Dr. David Langton, director of ExplantLab, a Newcastle-based organization that studies the links between genetics and the performance of medical devices who took part in the study, said: "There is little research into why joint replacements don't work in some patients. When a joint fails, it needs to be replaced and this poses a much greater risk of blood loss, infection and even death.

“Our findings are a big step towards giving patients more choice when choosing the type of joint implant and helping them make informed decisions about the associated risks.”

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Source: Dailymail UK

Genetic test to tell if your hip surgery will fail: Saliva swab could predict whether you will have an adverse reaction to a joint implant

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