Diabinesis (oral)

Diabinesis (oral)

Diabinesis (oral)

Uses for diabinesis

Proper nutrition is the first step in treating type 2 diabetes, but medication is often necessary. Chlorpropamide belongs to a class of drugs called sulfonylureas. It increases insulin secretion from the pancreas, which helps your body store sugar. This also reduces blood sugar levels and restores the way you use food for energy.

This medicine is only available with a doctor's prescription.

Before using Diabinese

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

No appropriate studies have been conducted on the relationship between age and the effects of chlorpropamide in children and adolescents. Safety and effectiveness have not been established.

geriatrics

Although appropriate studies have not been conducted on the relationship between age and the effects of chlorpropamide in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of chlorpropamide in the elderly. However, older patients are at higher risk of age-related liver or kidney problems, which may require dosage adjustments in patients receiving chlorpropamide.

Breastfeeding

There are insufficient studies in women to determine the risk to infants when using this drug while breast-feeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are taking this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

Using this medicine with any of the following medicines is not usually recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Abirateronacetat
• Acarbose
• Alogliptin
• Aspirin
• Bexagliflozin
• Chloroquin
• Chlorthiazid
• Chlorthalidon
• Ciprofloxacin
• Delafloxacin
• Desmopressin
• Disopyramid
• Dulaglutid
• Enoxacin
• Furosemid
• Gatifloxacin
• Gemifloxacin
• Grepafloxacin
• Hydrochlorothiazid
• Hydroflumethiazid
• Hydroxychloroquin
• Indapamid
• Insulin
• Insulin Aspart, rekombinant
• Insulin Rind
• Insulin Degludec
• Insulin Detemir
• Insulin Glargin, rekombinant
• Insulin Glulisin
• Insulin Lispro, rekombinant
• Lanreotid
• Levofloxacin
• Liraglutid
• Lixisenatid
• Lomefloxacin
• Metformin
• Methotrexat
• Metolazon
• Metreleptin
• Moxifloxacin
• Norfloxacin
• Octreotid
• Ofloxacin
• Pasireotid
• Pioglitazon
• Polythiazid
• Porfimer
• Pramlintide
• Semaglutid
• Sitagliptin
• Somatrogon-ghla
• Sotagliflozin
• Sparfloxacin
• Thioctsäure
• Triamteren
• Trovafloxacin

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Acebutolol
• Aminolävulinsäure
• Atenolol
• Betaxolol
• Bisoprolol
• Bittere Melone
• Carteolol
• Carvedilol
• Celiprolol
• Chloramphenicol
• Clofibrat
• Esmolol
• Bockshornklee
• Knoblauch
• Glucomannan
• Guarkernmehl
• Isocarboxazid
• Labetalol
• Levobunolol
• Linezolid
• Methylenblau
• Metipranolol
• Metoprolol
• Nadolol
• Nebivolol
• Oxprenolol
• Ozanimod
• Penbutolol
• Phenelzin
• Pindolol
• Practolol
• Procarbazin
• Propranolol
• Flohsamen
• Rasagilin
• Rifampin
• Rifapentin
• Safinamid
• Saxagliptin
• Selegilin
• Sotalol
• Timolol
• Tirzepatid
• Tranylcypromin

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine for any of the following conditions is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or frequency of use of this medication, or give you special instructions about food, alcohol, or tobacco consumption.

• Ethanol

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Alkoholvergiftung bzw
• Unteraktive Nebennieren bzw
• Hypophysenunterfunktion bzw
• Unterernährter Zustand bzw
• Geschwächte körperliche Verfassung – kann dazu führen, dass sich die Nebenwirkungen verschlimmern.

• Diabetische Ketoazidose (Ketone im Blut) oder
• Typ-I-Diabetes – sollte bei Patienten mit diesen Erkrankungen nicht angewendet werden.

• Glucose-6-Phosphat-Dehydrogenase (G6PD)-Mangel (ein Enzymproblem) – Mit Vorsicht anwenden. Kann bei Patienten mit dieser Erkrankung eine hämolytische Anämie (Bluterkrankung) verursachen.

• Erkrankungen des Herzens oder der Blutgefäße – mit Vorsicht anwenden. Kann diesen Zustand verschlimmern.

• Nierenerkrankung bzw
• Lebererkrankung – Mit Vorsicht anwenden. Die Wirkung kann durch die langsamere Entfernung des Arzneimittels aus dem Körper verstärkt werden.

Correct use of Diabinese

Carefully follow the special diet plan given to you by your doctor. This is the most important part of controlling your diabetes and is necessary for the medicine to work properly. Additionally, exercise regularly and test blood or urine sugar as directed.

You should take your medicine every morning with breakfast.

dosage

The dose of this medicine is different for different patients. Follow your doctor's instructions or the label directions. The following information includes average doses of this medicine only. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. In addition, the number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical problem for which you are using the medicine.

• Für orale Darreichungsform (Tabletten):
  • Bei Typ-2-Diabetes:
    • Erwachsene – zunächst 250 Milligramm (mg) einmal täglich. Ihr Arzt kann Ihre Dosis je nach Bedarf anpassen. Die Dosis beträgt normalerweise nicht mehr als 750 mg pro Tag.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Protect from freezing.

Keep away from children.

Do not keep medications that are outdated or no longer needed.

Ask your doctor how to throw away medicines you don't use.

Precautions when using Diabinese

It is very important that your doctor check your progress at regular visits. This will help your doctor determine whether the medicine is working properly and decide whether you should continue taking it. Blood and urine tests may be needed to check for adverse effects.

It is very important to carefully follow all instructions from your healthcare team:

• Alkohol – Alkoholkonsum kann zu einer starken Unterzuckerung des Blutzuckerspiegels führen. Besprechen Sie dies mit Ihrem Gesundheitsteam.
• Beratung – Andere Familienmitglieder müssen lernen, wie sie Nebenwirkungen verhindern oder bei auftretenden Nebenwirkungen helfen können. Außerdem benötigen Patienten mit Diabetes möglicherweise eine spezielle Beratung zu Dosierungsänderungen von Diabetesmedikamenten, die aufgrund von Änderungen des Lebensstils, wie z. B. Änderungen bei Bewegung und Ernährung, auftreten können. Darüber hinaus kann aufgrund der Probleme, die bei Patienten mit Diabetes während der Schwangerschaft auftreten können, eine Beratung zu Verhütung und Schwangerschaft erforderlich sein.
• Reisen: Nehmen Sie Ihr aktuelles Rezept und Ihre Krankengeschichte mit. Seien Sie wie gewohnt auf einen Notfall vorbereitet. Berücksichtigen Sie wechselnde Zeitzonen und halten Sie Ihre Essenszeiten so nah wie möglich an Ihren gewohnten Essenszeiten.
• Im Notfall: Es kann vorkommen, dass Sie bei einem durch Ihren Diabetes verursachten Problem Notfallhilfe benötigen. Auf diese Notfälle müssen Sie vorbereitet sein. Es empfiehlt sich, jederzeit ein medizinisches Identifikationsarmband oder eine Halskette zu tragen. Tragen Sie außerdem einen Ausweis in Ihrer Brieftasche oder Handtasche bei sich, aus dem hervorgeht, dass Sie an Diabetes leiden, sowie eine Liste aller Ihrer Medikamente.

Talk to your doctor immediately if you experience chest pain or discomfort. nausea; pain or discomfort in your arms, jaw, back, or neck; Shortness of breath; Sweat; or vomiting while using this medicine. These can be symptoms of a serious heart problem, including a heart attack.

Chlorpropamide can cause hypoglycemia (low blood sugar). However, this can also occur if you delay or skip a meal or snack, drink alcohol, exercise more than usual, are unable to eat because of nausea or vomiting, take certain medicines, or take chlorpropamide with other diabetes medications. The symptoms of low blood sugar must be treated before they lead to loss of consciousness (fainting). Different people experience different symptoms of low blood sugar. It's important that you know what symptoms of low blood sugar you typically experience so you can treat it quickly.

Symptoms of low blood sugar include anxiety; Behavioral change similar to drunkenness; blurred vision; cold sweat; Confusion; cool, pale skin; difficulty thinking; Sleepiness; excessive hunger; rapid heartbeat; headache (persistent); nausea; Nervousness; nightmares; restless sleep; Tremble; slurred speech; or unusual tiredness or weakness.

If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drinks, or sugar dissolved in water. Also, check your blood for low blood sugar levels. Glucagon is used in emergency situations when severe symptoms such as seizures or loss of consciousness occur. Have a glucagon kit and a syringe or needle ready and know how to use it. The members of your household should also know how to use it.

Do not take any other medicines unless you have discussed this with your doctor. This includes both prescription and nonprescription (over-the-counter [OTC]) medications and herbal or vitamin supplements.

Diabinesis side effects

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Consult your doctor immediately if any of the following side effects occur:

Rarely

• Bauch- oder Magenschmerzen
• Agitation
• schwarzer, teeriger Stuhl
• Schüttelfrost
• lehmfarbener Stuhlgang
• Koma
• Verwirrung
• anhaltender Durchfall
• anhaltende Magenschmerzen
• Krämpfe
• dunkler Urin
• verminderte Urinausscheidung
• Depression
• Durchfall
• Schwindel
• schneller oder unregelmäßiger Herzschlag
• Fieber
• Kopfschmerzen
• Feindseligkeit
• Erhöhter Durst
• Reizbarkeit
• Juckreiz
• Lethargie
• Appetitverlust
• Muskelschmerzen oder Krämpfe
• Muskelzuckungen
• Übelkeit oder Erbrechen
• schnelle Gewichtszunahme
• Ausschlag
• Anfälle
• Kurzatmigkeit
• Stupor
• Schwellung des Gesichts, der Knöchel oder Hände
• unangenehmer Atemgeruch
• ungewöhnliche Müdigkeit oder Schwäche
• Erbrechen von Blut
• gelbe Augen oder Haut

Incident not known

• Angst
• Rücken-, Bein- oder Bauchschmerzen
• Zahnfleischbluten
• Blut im Urin oder Stuhl
• verschwommene Sicht
• Brustschmerzen
• kalter Schweiß
• kühle, blasse Haut
• Husten oder Heiserkeit
• Depression
• Schwierigkeiten beim Atmen
• Fieber mit oder ohne Schüttelfrost
• Mit Flüssigkeit gefüllte Hautblasen
• allgemeine Schwellung des Körpers
• allgemeines Gefühl von Müdigkeit oder Schwäche
• Kopfschmerzen
• hohes Fieber
• erhöhter Hunger
• Schmerzen im unteren Rücken oder an der Seite
• Nervosität
• Albträume
• Nasenbluten
• schmerzhaftes oder schwieriges Wasserlassen
• Punktgenaue rote Flecken auf der Haut
• Empfindlichkeit gegenüber der Sonne
• Zittern
• dünne Haut
• undeutliches Sprechen
• Halsentzündung
• Wunden, Geschwüre oder weiße Flecken auf den Lippen oder im Mund
• geschwollene oder schmerzhafte Drüsen
• Engegefühl in der Brust
• ungewöhnliche Blutungen oder Blutergüsse
• keuchend

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Verdauungsstörungen
• Gasdurchgang

Less common

• Nesselsucht oder Striemen
• Rötung der Haut
• Gewichtsverlust

Rarely

• Blasenbildung, Abschälen oder Lockerung der Haut
• Risse in der Haut
• Wärmeverlust des Körpers
• rote, gereizte Augen
• rote, geschwollene Haut
• schuppige Haut

Incident not known

• Erhöhte Empfindlichkeit der Haut gegenüber Sonnenlicht
• Rötungen oder andere Verfärbungen der Haut
• schwerer Sonnenbrand

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Diabinesisch

Available dosage forms:

• Tablette

Therapeutic Class: Hypoglycemic

Chemical Class: 1st generation sulfonylurea

More information