Duraclone (Epidural)

Duraclone (Epidural)

Duraclon (Epidural) Epidural route (solution)

The product with a strength of 500 mcg/ml should be diluted in an appropriate solution before use. Epidural clonidine is not recommended for obstetric, postpartum, or perioperative pain management. The risk of hemodynamic instability, particularly hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. However, in a rare obstetric, postpartum, or perioperative patient, the potential benefits may outweigh the possible risks.

Uses for Duraclon

Clonidine must be started under the immediate supervision of your doctor. After your doctor determines how you react to clonidine, you may be able to receive this medicine at home.

This medicine is only available with a doctor's prescription.

Before using Duraclon

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

Although there is no specific information comparing the use of clonidine in children with its use in other age groups, this drug is not expected to cause any different side effects or problems in children than in adults. This medicine is usually only used in children when the pain is severe and other painkillers have not helped.

geriatrics

Many drugs have not been specifically studied in older people. Therefore, it may not be known whether they work the same way as they do in younger adults or whether they cause different side effects or problems in older people. There is no specific information comparing the use of clonidine in the elderly with use in other age groups.

Breastfeeding

Studies suggest that this medication may alter milk production or composition. If no alternative to this medication is prescribed, monitor the infant for side effects and adequate milk intake.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are taking this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

Using this medicine with any of the following medicines is not usually recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Acebutolol
• Amitriptylin
• Amoxapin
• Atenolol
• Betaxolol
• Bevantolol
• Bisoprolol
• Carteolol
• Celiprolol
• Ceritinib
• Clomipramin
• Crizotinib
• Desipramin
• Dilevalol
• Diltiazem
• Dothiepin
• Doxepin
• Esmolol
• Imipramin
• Iobenguane I 131
• Levobunolol
• Lofepramin
• Macimorelin
• Metipranolol
• Metoprolol
• Mirtazapin
• Nadolol
• Nebivolol
• Nortriptylin
• Oxprenolol
• Penbutolol
• Pindolol
• Propranolol
• Protriptylin
• Sotalol
• Tertatolol
• Timolol
• Trimipramin
• Verapamil

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Cyclosporin
• Fluphenazin
• Mepivacain
• Naloxon
• Yohimbin

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. Discuss using your medicine with food, alcohol or tobacco with your doctor.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Antikoagulanzientherapie bzw
• Blutungsprobleme – Blutungen in den Bereich um das Rückenmark sind möglich

• Herz- oder Blutgefäßerkrankung – Clonidin kann diese Erkrankungen verschlimmern

• Infektion an der Injektionsstelle oder am Katheter (Schlauch) – Das Risiko einer Meningitis oder eines Abszesses ist erhöht

• Nierenerkrankung – Die Wirkung von Clonidin kann aufgrund der langsameren Entfernung von Clonidin aus dem Körper verstärkt werden

• Schmerzen im Zusammenhang mit einer Operation oder
• Schmerzen während oder nach der Geburt – Die Fähigkeit, einige der möglichen Nebenwirkungen von Clonidin zu tolerieren, kann beeinträchtigt sein

Proper use of Duraclon

Clonidine is given continuously as an epidural infusion (run around the spinal cord) using an infusion pump. The pump and its tubing should be checked regularly to ensure that clonidine flow is not accidentally stopped. The injection or catheter site should also be checked regularly for signs of infection.

If you are using this medicine at home, make sure you understand exactly how to use it.

dosage

The dose of this medicine is different for different patients. Follow your doctor's instructions or the label directions. The following information includes average doses of this medicine only. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. In addition, the number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical problem for which you are using the medicine.

• Für die Injektionsdosisform:
  • Für Schmerzen:
    • Erwachsene – 30 µg pro Stunde, verabreicht als Dauerinfusion.
    • Kinder – Die Dosierung richtet sich nach dem Körpergewicht und muss von Ihrem Arzt festgelegt werden.

Missed dose

Call your doctor or pharmacist for instructions.

Tell your doctor immediately if you think you have stopped taking clonidine for any reason.

storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Protect from freezing.

Keep away from children.

Do not keep medications that are outdated or no longer needed.

Precautions when using Duraclon

This medicine should not be stopped without medical supervision. If clonidine is suddenly stopped, serious side effects may occur.

This medicine can increase the effects of alcohol and other CNS depressants (medicines that can make you sleepy or less alert). Consult your doctor before taking such depressants while using this medicine.

Dizziness, lightheadedness or fainting can occur, especially when getting up from a lying or sitting position. Getting up slowly can be helpful.

This medicine may cause some people to feel sleepy or less alert than usual. Make sure you know how you react to this medicine before driving, operating machinery, or doing other work that requires you to be alert.

Side effects of Duraclone

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Contact your doctor as soon as possible if any of the following side effects occur:

More common

• Schwindel, Benommenheit oder Ohnmacht
• langsamer Herzschlag

Less common

• Brustschmerzen
• extrem flache oder langsame Atmung
• schneller Herzschlag
• Fieber
• Halluzinationen (Sehen, Fühlen oder Hören von Dingen, die nicht da sind)
• mentale Depression
• Schläfrigkeit (übermäßig)
• Erbrechen

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Angst
• Verwirrung
• trockener Mund
• Brechreiz
• Schläfrigkeit

Less common

• Verstopfung
• Klingeln, Summen oder andere unerklärliche Geräusche in den Ohren
• Schwitzen, ungewöhnlich
• Schwäche

After you stop using this medicine, you may still experience side effects that require treatment. During this time, talk to your doctor immediately if you notice the following side effects:

• Agitation
• Kopfschmerzen
• Nervosität
• hämmernder Herzschlag
• Zittern oder Zittern

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Duraclon

Available dosage forms:

• Lösung

Therapeutic class: Analgesic

Pharmacological class: Alpha-2 adrenergic agonist

More information