Dyclonine (monograph)

Dyclonine (monograph)

Dyclonine (monograph)

introduction

Local anesthesia.

Uses for Dyclonine

Oral/throat analgesia/anesthesia

In fixed combination with menthol as self-medication for the temporary relief of occasional mild irritation, aches or pains in the mouth or throat, as well as coughs associated with a cold or inhaled irritants.

Local anesthesia

Has been used as a local anesthetic before laryngoscopy, bronchoscopy, esophagoscopy or endotracheal intubation. However, oral solutions are no longer commercially available in the United States.

Dosage and administration of dyclonine

Administration

Oral administration

Administer orally as a lozenge.

Allow the lozenge to slowly dissolve in your mouth; Do not bite or chew on it.

dosage

Pediatric patients

Mouth/sore throat

Orally

Children ≥2 years: 1 lozenge (1.2, 2 or 3 mg); Repeat after 2 hours if necessary.

Adult

Mouth/sore throat

Orally

1 lozenge (1.2, 2 or 3 mg); Repeat after 2 hours if necessary.

Prescription Limits

Pediatric patients

Mouth/sore throat

Orally

Children ≥2 years: Maximum of 10 lozenges daily. Not for self-medication if you have a sore throat >2 days or a sore mouth >7 days.

Adult

Mouth/sore throat

Orally

A maximum of 10 lozenges daily. Not for self-medication if you have a sore throat >2 days or a sore mouth >7 days.

Special populations

There are currently no specific dosage recommendations for the population.

Precautions for Dyclonine

Contraindications

• Known hypersensitivity to dyclonine or any of the components of the formulation.

Warnings/Precautions

Sensitivity reactions

Allergic reactions

Use with caution in patients with a known allergy to dyclonine.

Sensitization and allergic reactions are rare. Possible hypersensitivity reactions to anesthetics can manifest themselves as delayed-onset skin lesions, urticaria, swelling and edema.

General precautions

Systemic effects

Systemic (e.g., CNS, cardiovascular) effects are possible with excessive dosage or rapid absorption of dyclonine.

Adverse central nervous system effects may include agitation and/or depression, nervousness, dizziness, blurred vision or tremor followed by seizures, unconsciousness, drowsiness and possibly respiratory arrest.

Cardiovascular side effects may include myocardial depression, hypotension, bradycardia, and cardiac arrest.

Patient monitoring

If the sore throat is severe or persistent (e.g., longer than 2 days) or is associated with or accompanied by high fever, persistent headache, rash, swelling, irritation, and nausea, discontinue the medication and consult a doctor.

If mouth sore symptoms do not improve after 7 days, discontinue the medication and consult a doctor.

infection or trauma

Use with extreme caution in areas with traumatized mucosa and/or if sepsis is present in the intended area of ​​use.

Using a fixed combination

When used in fixed combination with other active ingredients, the precautions, cautions and contraindications associated with the concomitant active ingredients must be observed.

Specific populations

pregnancy

Safety in pregnant women has not been established. The manufacturers state that pregnant women should consult a doctor before use.

lactation

The manufacturers state that breastfeeding women should consult a doctor before use.

Pediatric use

The safety of dyclonine lozenges in children younger than 2 years has not been established; Before use on such patients, consult a doctor or dentist.

Common side effects

Irritation, stinging.

Pharmacokinetics of dyclonine

absorption

beginning

After topical application of a 0.5 or 1 percent dyclonine solution (both no longer commercially available in the United States) to mucous membranes, local anesthesia occurs within 2 to 10 minutes.

Length of time

After topical application of a 0.5 or 1 percent dyclonine solution, anesthesia lasts for approximately 30 minutes.

stability

storage

Orally

Lozenges

Protect from excessive heat (temperatures >38°C).

Actions

• Local anesthetic and analgesic.

Advice for patients

• Advise patients to suck the lozenge rather than chewing or biting it.

• Advise patients to consult a physician before use if they have a chronic cough secondary to smoking, asthma or emphysema, or a cough with excessive mucus.

• Advise patients to discontinue the medication and consult a physician if symptoms of sore throat or cough do not improve after 2 days or if symptoms of mouth sore do not improve after 7 days.

• If irritation, pain or hypersensitivity occurs, discontinue use and consult a doctor or dentist.

• It is important to inform the doctor about any existing or planned concomitant therapies, including prescription and over-the-counter medicines, as well as any comorbidities.

• It is important for women to tell doctors if they are pregnant, plan to become pregnant, or want to breastfeed.

• It is important to inform patients of other important precautionary information. (See Precautions.)

Preparations

Excipients in commercial drug preparations may have clinically significant effects in some individuals; Details can be found on the respective product labeling.

For information about shortages of one or more of these drugs, visit the ASHP Drug Shortages Resource Center.

* Available from one or more manufacturers, distributors and/or repackagers under generic (non-proprietary) names

Dyclonine hydrochloride

Dyclonine hydrochloride combinations

AHFS DI Essentials™. © Copyright 2024, Selected changes February 1, 2008. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

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