Factor V suffering

Factor V suffering

overview

Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation may increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.

Most people with factor V Leiden never develop abnormal blood clots. But in people who do, these abnormal clots can cause long-term health problems or become life-threatening.

Both men and women can have factor V disease. Women with the factor V Leiden mutation may have an increased tendency to form blood clots during pregnancy or while taking the hormone estrogen.

If you have factor V Leiden and have developed blood clots, anticoagulant medications can reduce your risk of developing additional blood clots and help you avoid potentially serious complications.

Symptoms

The factor V Leiden mutation itself does not cause any symptoms. Because factor V Leiden puts you at risk for blood clots forming in the leg or lung, the first sign that you have this condition may be the development of an abnormal blood clot.

Some clots do no harm and go away on their own. Others can be life-threatening. The symptoms of a blood clot depend on which part of your body is affected.

A clot in a deep vein

This is called deep vein thrombosis (DVT) and most commonly occurs in the legs. A DVT may not cause any symptoms. When signs and symptoms occur, they may include:

• Schmerzen
• Schwellung
• Rötung
• Wärme

A clot that travels to your lungs

This is called a pulmonary embolism and occurs when part of a DVT breaks off and travels through the right side of your heart to your lungs, where it blocks blood flow. This can be a life-threatening situation. Signs and symptoms can include:

• Plötzliche Atemnot
• Brustschmerzen beim einatmen
• Ein Husten, der blutigen oder blutigen Auswurf produziert
• Schneller Herzschlag

When to go to the doctor?

Seek immediate medical attention if you have any signs or symptoms of DVT or pulmonary embolism.

Causes

If you have factor V Leiden, you have inherited either one copy or, rarely, two copies of the defective gene. Inheriting one copy slightly increases your risk of developing blood clots. Inheriting two copies - one from each parent - significantly increases the risk of developing blood clots.

Risk factors

A family history of factor V Leiden increases your risk of inheriting the disease. The disorder is most common in people who are white and of European descent.

People who inherited factor V Leiden from just one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Factors that increase this risk include:

• Zwei fehlerhafte Gene. Das Erben der genetischen Mutation von beiden Elternteilen statt nur von einem Elternteil kann Ihr Risiko für anormale Blutgerinnsel erheblich erhöhen.
• Unbeweglichkeit. Längere Phasen der Immobilität, wie z. B. Sitzen während eines langen Flugs, können das Risiko von Beinklumpen erhöhen.
• Östrogene. Orale Kontrazeptiva, Hormonersatztherapie und Schwangerschaft können die Wahrscheinlichkeit erhöhen, dass Sie Blutgerinnsel entwickeln.
• Operationen oder Verletzungen. Operationen oder Verletzungen wie Knochenbrüche können Ihr Risiko für anormale Blutgerinnsel erhöhen.
• Nicht-O-Blutgruppe. Anormale Blutgerinnsel treten häufiger bei Menschen mit den Blutgruppen A, B oder AB auf als bei Menschen mit Blutgruppe O.

Complications

Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). These blood clots can be life-threatening.

Sources:

1. Faktor-V-Leiden-Thrombophilie. Informationszentrum für Genetik und seltene Krankheiten. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Abgerufen am 4. Juni 2018.
2. Bauer KA. Faktor-V-Leiden und aktivierte Protein-C-Resistenz. https://www.uptodate.com/contents/search. Abgerufen am 4. Juni 2018.
3. Fragen Sie MayoExpert. Faktor V Leiden. Rochester, Minnesota: Mayo Foundation for Medical Education and Research; 2018.
4. Venöse Thromboembolie. Nationales Institut für Herz, Lunge und Blut. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Abgerufen am 4. Juni 2018.
5. Kaushansky K., et al., Hrsg. Erbliche Thrombophilie. In: Williams Hämatologie. 9. Aufl. New York, NY: McGraw-Hill-Bildung; 2016. https://accessmedicine.mhmedical.com. Abgerufen am 4. Juni 2018.
6. Lockwood CJ, et al. Vererbte Thrombophilien in der Schwangerschaft. https://www.uptodate.com/contents/search. Abgerufen am 4. Juni 2018.
7. Pruthi RK (Gutachten). Mayo Clinic, Rochester, Minnesota, 17. Juni 2018.
8. Barbara Woodward Lips Patientenschulungszentrum. Tiefe Venenthrombose und Lungenembolie. Rochester, Minnesota: Mayo Foundation for Medical Education and Research; 2017.