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Common variable immunodeficiency
Common variable immunodeficiency
overview
Common Variable Immunodeficiency (CVID) is a disorder of the immune system that causes you to have low levels of the proteins that help fight infections. If you have CVID, you will likely have recurring infections in your ears, sinuses, and respiratory tract. You also have an increased risk of digestive disorders, autoimmune diseases, blood disorders and cancer. CVID can be inherited or you can develop it throughout your life.
Symptoms
The severity of symptoms can vary greatly between people with CVID. Symptoms of common variable immunodeficiency can appear in childhood or adolescence, although many people do not experience them until adulthood.
If you have CVID, you will likely experience repeated infections before you are diagnosed. The most common types of infections are pneumonia, sinusitis, ear infections and gastrointestinal infections.
Causes
In the vast majority of CVID cases, the cause is unknown. A genetic mutation has been identified in about 10% of people with CVID. Researchers believe the condition is caused by a combination of environmental and genetic factors. So far, the environmental factors are unclear.
Common variable immunodeficiency care
Sources:
- Common Variable Immunodeficiency (CVID). Amerikanische Akademie für Allergie, Asthma und Immunologie. https://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease/common-variable-immunodeficiency. Abgerufen am 29. Januar 2020.
- Bennett JE, et al. Adaptive Immunität: Antikörper und Immundefekte. In: Prinzipien und Praxis von Infektionskrankheiten von Mandell, Douglas und Bennett. 9. Aufl. Elsevier; 2020. https://www.clinicalkey.com. Abgerufen am 27. Januar 2020.
- Gemeinsame variable Immunschwäche. Genetik-Home-Referenz. https://ghr.nlm.nih.gov/condition/common-variable-immune-deficiency#definition. Abgerufen am 27. Januar 2020.
- Braun AY. Allscripts EPSi. Mayo-Klinik. 14. November 2019.
- Goldman L. et al., Hrsg. Primäre Immunschwächekrankheiten. In: Goldman-Cecil Medicine. 26. Aufl. Elsevier; 2020. https://www.clinicalkey.com. Abgerufen am 27. Januar 2020.