Lorazepam (oral)

Lorazepam (oral)

Oral route (capsule, extended release; tablet)

Risks associated with concurrent use with opioids; abuse, misuse and addiction; and dependence and withdrawal reactions:

Concomitant use of benzodiazepines and opioids may cause profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and duration to the minimum necessary. Observe patients for signs and symptoms of respiratory depression and sedation.

The use of benzodiazepines, including lorazepam, exposes users to the risk of misuse, misuse, and addiction, which can lead to overdose or death. Misuse and misuse of benzodiazepines are often accompanied by concomitant use of other medications, alcohol and/or illicit substances, which is associated with an increased frequency of serious adverse consequences. Before prescribing lorazepam and throughout treatment, assess each patient's risk for misuse, misuse, and addiction.

Continued use of benzodiazepines, including lorazepam, may result in clinically significant physical dependence. The risk of dependence and withdrawal increases with longer duration of treatment and higher daily dosage. Abrupt discontinuation or rapid dose reduction of lorazepam after continued use may result in acute withdrawal reactions, which may be life-threatening. To reduce the risk of withdrawal reactions, you should gradually discontinue lorazepam or reduce the dosage.

Uses for lorazepam

This medicine is only available with a doctor's prescription.

Before using lorazepam

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

Appropriate studies have not been conducted on the relationship between age and the effects of lorazepam tablets and oral fluid in children under 12 years of age and of extended-release capsules in children. Safety and effectiveness have not been established.

geriatrics

Studies conducted to date have not shown any geriatric-specific problems that would limit the benefit of lorazepam in the elderly. However, older patients are at higher risk of adverse effects (e.g., severe sleepiness or agitation) and age-related kidney, liver, or heart problems, which may require caution and dose adjustment.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are taking this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or to change some of the other medications you are taking.

• Flumazenil

Using this medicine with any of the following medicines is not usually recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Alfentanil
• Alprazolam
• Amobarbital
• Anileridin
• Aripiprazol
• Benzhydrocodon
• Bromazepam
• Bromoprid
• Buprenorphin
• Butabarbital
• Butalbital
• Butorphanol
• Calcifediol
• Calciumoxybat
• Cannabidiol
• Cannabis
• Carbinoxamin
• Carisoprodol
• Cetirizin
• Chloralhydrat
• Chlorzoxazon
• Clobazam
• Clonazepam
• Kodein
• Dantrolen
• Daridorexant
• Dexmedetomidin
• Dezocine
• Diacetylmorphin
• Difenoxin
• Dihydrocodein
• Diphenoxylat
• Doxylamin
• Esketamin
• Ethchlorvinyl
• Ethylmorphin
• Fentanyl
• Flibanserin
• Fospropofol
• Gabapentin
• Gabapentin Enacarbil
• Hydrocodon
• Hydromorphon
• Ivacaftor
• Ketamin
• Ketobemidon
• Lacosamid
• Lemborexant
• Levocetirizin
• Levorphanol
• Lofexidin
• Loxapin
• Magnesiumoxybat
• Meclizin
• Meperidin
• Mephenesin
• Mephobarbital
• Meprobamat
• Meptazinol
• Metaxalone
• Methadon
• Methocarbamol
• Methohexital
• Metoclopramid
• Midazolam
• Mirtazapin
• Morphium
• Morphinsulfat-Liposom
• Nalbuphin
• Nicomorphin
• Opium
• Opiumalkaloide
• Orlistat
• Oxycodon
• Oxymorphon
• Papaveretum
• Paregorisch
• Pentazocin
• Pentobarbital
• Periciazin
• Phenobarbital
• Piritramid
• Kaliumoxybat
• Pregabalin
• Primidon
• Propofol
• Remifentanil
• Remimazolam
• Ropeginterferon Alfa-2b-njft
• Scopolamin
• Secobarbital
• Natriumoxybat
• Sufentanil
• Tapentadol
• Thiopental
• Tilidin
• Topiramat
• Tramadol
• Trazodon
• Zolpidem
• Zuranolon

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Desogestrel
• Dienogest
• Drospirenon
• Östradiol
• Ethinylestradiol
• Ethynodiol
• Gestoden
• Levonorgestrel
• Mestranol
• Nomegestrol
• Norethindron
• Norgestimate
• Norgestrel
• Posaconazol
• Probenecid
• Pyrimethamin
• Rifapentin
• Johanniskraut
• Theophyllin
• Valproinsäure

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. The following interactions were selected for their potential significance and are not necessarily exhaustive.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Alkohol- oder Drogenmissbrauch oder -abhängigkeit oder Vorgeschichte von oder
• Lungen- oder Atemprobleme (z. B. COPD, Atemdepression, Schlafapnoe) oder
• Anfälle oder Anfälle in der Vorgeschichte: Mit Vorsicht anwenden. Kann diese Bedingungen verschlimmern.

• Depression bzw
• Psychische Probleme (z. B. Psychose) – Die Anwendung wird bei Patienten mit diesen Erkrankungen nicht empfohlen.

• Glaukom, akutes Engwinkelglaukom – Sollte bei Patienten mit dieser Erkrankung nicht angewendet werden.

• Nierenerkrankung bzw
• Lebererkrankung – Mit Vorsicht anwenden. Die Wirkung kann durch die langsamere Entfernung des Arzneimittels aus dem Körper verstärkt werden.

Proper use of lorazepam

Only take this medicine as directed by your doctor. Do not take more of it, do not take it more often, or take it for longer than your doctor prescribed. If too much of this medicine is taken over a long period of time, it may become habit-forming (leading to mental or physical dependence).

This medicine should be accompanied by a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole. Do not crush, break or chew it.

Swallow the extended-release capsule whole. Do not crush, break or chew it. If you cannot swallow the extended-release capsule, you can open it and sprinkle the medicine on a tablespoon of applesauce. Stir this mixture well and swallow it whole. Drink water after swallowing the mixture. Take the mixture within 2 hours of mixing. Do not store for later use.

Measure the oral fluid using the labeled medication pipette included in the package. Dilute each dose with water, juice, lemonade, applesauce, and pudding.

dosage

The dose of this medicine is different for different patients. Follow your doctor's instructions or the label directions. The following information includes average doses of this medicine only. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. In addition, the number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical problem for which you are using the medicine.

• Für die orale Darreichungsform (Lösung zum Einnehmen):
  • Bei Angst:
    • Erwachsene und Kinder ab 12 Jahren – 2 bis 6 Milligramm (mg) in aufgeteilten Dosen pro Tag. Ihr Arzt kann Ihre Dosis je nach Bedarf anpassen.
    • Ältere Erwachsene – zunächst 1 bis 2 mg in mehreren Dosen pro Tag. Ihr Arzt kann Ihre Dosis je nach Bedarf anpassen.
    • Kinder unter 12 Jahren – Anwendung und Dosierung müssen von Ihrem Arzt festgelegt werden.
• Für orale Darreichungsform (Tabletten):
  • Bei Angst:
    • Erwachsene und Kinder ab 12 Jahren – zunächst 2 bis 3 Milligramm (mg) in mehreren Dosen pro Tag. Ihr Arzt kann Ihre Dosis je nach Bedarf anpassen.
    • Ältere Erwachsene – zunächst 1 bis 2 mg in mehreren Dosen pro Tag. Ihr Arzt kann Ihre Dosis je nach Bedarf und Verträglichkeit anpassen.
    • Kinder unter 12 Jahren – Anwendung und Dosierung müssen von Ihrem Arzt festgelegt werden.
  • Bei Schlaflosigkeit, die durch Angstzustände oder vorübergehenden Situationsstress verursacht wird:
    • Erwachsene und Kinder ab 12 Jahren – 2 bis 4 Milligramm (mg), eingenommen als Einzeldosis vor dem Schlafengehen. Ihr Arzt kann Ihre Dosis je nach Bedarf anpassen.
    • Kinder unter 12 Jahren – Anwendung und Dosierung müssen von Ihrem Arzt festgelegt werden.
• Für die orale Darreichungsform (Retardkapseln):
  • Bei Angst:
    • Erwachsene: Eine Kapsel einmal täglich morgens. Die Dosierung richtet sich nach der gesamten Tagesdosis an Lorazepam-Tabletten, die Sie dreimal täglich in gleichmäßig verteilten Dosen einnehmen. Ihr Arzt kann Ihre Dosis je nach Bedarf anpassen.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Protect from freezing.

Keep away from children.

Do not keep medications that are outdated or no longer needed.

Ask your doctor how to throw away medicines you don't use.

Precautions when using lorazepam

It is very important that your doctor checks you or your child's progress at regular visits to see if this medicine is working and to consider changes in the dose. Blood tests may be needed to check for adverse effects.

Tell your doctor if you are pregnant or planning to become pregnant. Using this medicine later in pregnancy may cause problems in your newborn baby (such as sedation or withdrawal symptoms). Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, problems feeding, a high-pitched cry, irritability, low muscle tone, restlessness, shaking or shaking, sluggishness, difficulty breathing, weight loss, vomiting, or failing to gain weight. If you think you have become pregnant while using this medicine, tell your doctor immediately.

This medicine can be habit forming. If you feel that the medicine is not working as well, do not take more than the prescribed dose. Call your doctor for instructions.

If you develop unusual and strange thoughts or behavior while taking lorazepam, be sure to discuss this with your doctor. Some changes that have occurred in people taking this medicine are similar to those seen in people who drink alcohol and then behave in ways that are not normal. Other changes may be more unusual and extreme, such as confusion, worsening depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual agitation, nervousness, or irritability.

This medicine may cause drowsiness, trouble thinking, difficulty controlling movements, or difficulty seeing clearly. Make sure you know how you react to this medicine before driving, operating machinery, or doing other activities that could be dangerous if you are not alert or unable to think or see well.

Symptoms of overdose include: blurred vision, changes in consciousness, confusion, dizziness, fainting or light-headedness when standing up suddenly from lying or sitting, hallucinations, increased sweating, loss of consciousness, loss of strength or energy, muscle pain, etc. Weakness, nightmares, tremors and unsteady gait, slow or irregular heartbeat, sweating, difficulty speaking, unsteadiness, tremors or other problems with muscle control or -coordination, trouble sleeping, unusual agitation, nervousness, restlessness or irritability, or unusual tiredness or weakness. Call your doctor immediately if you notice these symptoms.

This medicine may cause respiratory depression (severe breathing problems that can be life-threatening), especially when used with narcotic painkillers. Tell your doctor if you are taking narcotics.

Do not stop taking it without first consulting your doctor. Your doctor may want you to gradually reduce the amount you take before stopping it completely. This can help prevent your condition from worsening and reduce the possibility of withdrawal symptoms such as hallucinations, headaches, seizures, stomach or muscle cramps, tremors, trouble sleeping, or unusual behavior.

This medicine increases the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants include antihistamines or medications for hay fever, allergies, or colds, sedatives, sedatives, or sleeping pills, prescription pain relievers or narcotics, barbiturates or anti-seizure medications, muscle relaxants, or anesthetics (numbing medications), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Consult your doctor before taking any of the above medicines while using this medicine.

Do not take any other medicines unless you have discussed this with your doctor. This includes both prescription and nonprescription (over-the-counter [OTC]) medications and herbal or vitamin supplements.

Lorazepam side effects

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Consult your doctor immediately if any of the following side effects occur:

More common

• Schläfrigkeit
• entspannt und ruhig
• Schläfrigkeit

Incident not known

• Aggressiv, wütend
• Agitation
• Angriff, Angriff oder Gewalt
• schwarzer, teeriger Stuhl
• Zahnfleischbluten
• Blut im Urin oder Stuhl
• bläuliche Lippen oder Haut
• verschwommene Sicht
• Veränderung im Bewusstsein
• Engegefühl in der Brust
• Schüttelfrost
• Koma
• Verwirrung
• Verwirrung über Identität, Ort und Zeit
• Husten oder Heiserkeit
• dunkler Urin
• verminderte Urinausscheidung
• Schwierigkeiten beim Atmen oder Schlucken
• Schwierigkeiten beim Sprechen
• Entmutigung
• Schwindel, Ohnmacht oder Benommenheit beim plötzlichen Aufstehen aus einer liegenden oder sitzenden Position
• sabbern
• trockener Mund
• Erregung
• falsches oder ungewöhnliches Wohlbefinden
• schneller oder unregelmäßiger Herzschlag
• sich traurig oder leer fühlen
• Fieber mit oder ohne Schüttelfrost
• allgemeines Gefühl von Müdigkeit oder Schwäche
• Kopfschmerzen
• Nesselsucht, Juckreiz oder Hautausschlag
• Hyperventilation
• Erhöhter Durst
• unregelmäßige, schnelle oder langsame oder flache Atmung
• Reizbarkeit
• Appetitverlust
• Verlust der Gleichgewichtskontrolle
• Bewusstlosigkeit
• Verlust von Interesse oder Vergnügen
• Gedächtnisverlust
• Schmerzen im unteren Rücken oder an der Seite
• Muskelschmerzen, Krämpfe, Zittern, Zuckungen oder Steifheit
• Übelkeit oder Erbrechen
• nicht atmen
• schmerzhaftes oder schwieriges Wasserlassen
• blasse oder blaue Lippen, Fingernägel oder Haut
• Punktgenaue rote Flecken auf der Haut
• Probleme mit dem Gedächtnis
• Schwellungen oder Schwellungen der Augenlider oder um die Augen, das Gesicht, die Lippen oder die Zunge
• Rötung der Haut, insbesondere um die Ohren
• Unruhe
• Dinge sehen, hören oder fühlen, die nicht da sind
• Anfälle
• zittern
• schlurfender Gang
• Halsentzündung
• Wunden, Geschwüre oder weiße Flecken auf den Lippen oder im Mund
• Steifheit der Gliedmaßen
• Magenschmerzen
• Schwitzen
• Schwellung der Augen oder der Innenseite der Nase
• Schwellung des Gesichts, der Knöchel oder Hände
• geschwollene Drüsen
• Gedanken oder Selbstmordversuche
• Konzentrationsschwierigkeiten
• Schlafstörungen
• Drehbewegungen des Körpers
• unkontrollierte Bewegungen, insbesondere von Gesicht, Hals und Rücken
• unerklärliche Blutungen oder Blutergüsse
• unangenehmer Atemgeruch
• ungewöhnliche Blutungen oder Blutergüsse
• ungewöhnliche Müdigkeit oder Schwäche
• Erbrechen von Blut
• gelbe Augen oder Haut

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Agitation
• Veränderungen in den Mustern und Rhythmen der Sprache
• Verwirrung
• Aufregung
• vermehrtes Schwitzen
• Reizbarkeit
• Verlust von Kraft oder Energie
• Albträume
• Unruhe
• Zittern und unsicherer Gang
• undeutliches Sprechen
• Gesprächigkeit
• Schwierigkeiten beim Sprechen
• Unsicherheit, Zittern oder andere Probleme mit der Muskelkontrolle oder -koordination
• ungewöhnliche Schläfrigkeit, Mattheit, Müdigkeit, Schwäche oder Trägheitsgefühl
• ungewöhnliche Erregung, Nervosität, Unruhe oder Reizbarkeit
• ungewöhnliche Blässe
• ungewöhnliches Schwächegefühl

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

Incident not known

• Vergesslich sein
• Ungeschicklichkeit
• Verstopfung
• vermindertes Interesse am Geschlechtsverkehr
• gestörte Farbwahrnehmung
• Schwindel oder Benommenheit
• Doppeltsehen
• Schläfrigkeit
• Gefühl der ständigen Bewegung von sich selbst oder der Umgebung
• Haarausfall oder Haarausfall
• Lichthöfe um Lichter
• Unfähigkeit, eine Erektion zu haben oder aufrechtzuerhalten
• Steigerung der sexuellen Fähigkeiten, des Verlangens, des Antriebs oder der Leistung
• erhöhtes Interesse am Geschlechtsverkehr
• Mangel oder Verlust der Selbstkontrolle
• Lethargie
• Verlust der sexuellen Fähigkeiten, des Verlangens, des Antriebs oder der Leistung
• Muskelschmerzen, Zuckungen oder Schwäche
• nacht Blindheit
• zu helles Erscheinungsbild der Lichter
• schnelle Gewichtszunahme
• Gefühl des Drehens
• Zittern in den Beinen, Armen, Händen oder Füßen
• Zittern
• Stupor
• Zittern oder Zittern der Hände oder Füße
• Tunnelblick
• schwacher oder schwacher Puls

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Ativan
• Lorazepam Intensol
• Loreev XR

Available dosage forms:

• Tablette
• Lösung
• Kapsel, verlängerte Veröffentlichung

Therapeutic class: anti-anxiety

Pharmacological class: Benzodiazepine, short- or intermediate-acting

• Lorazepam vs. Xanax: Was ist der Unterschied?
• Ativan vs. Xanax – Was ist der Unterschied?

More information