Mesna (intravenous)

Mesna (intravenous)

Mesna (intravenous)

Uses for Mesna

This medicine should only be administered by or under your doctor's direct supervision.

Before using Mesna

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

No appropriate studies have been conducted on the relationship between age and the effects of Mesna injection in children and adolescents. Safety and effectiveness have not been established.

geriatrics

Related studies conducted to date have not shown any geriatric-specific problems that would limit the benefit of Mesna injection in the elderly. However, older patients are at higher risk of age-related liver, kidney, and heart problems, which may require caution and dose adjustment in patients receiving Mesna injection.

Breastfeeding

Studies suggest that this medication may alter milk production or composition. If no alternative to this medication is prescribed, monitor the infant for side effects and adequate milk intake.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are receiving this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Warfarin

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. Discuss using your medicine with food, alcohol or tobacco with your doctor.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Allergie gegen Thiolverbindungen (z. B. Amifostin), Vorgeschichte von – Mit Vorsicht anwenden. Kann das Risiko eines erneuten Auftretens einer allergischen Reaktion erhöhen.

Proper use of mesna

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle inserted into one of your veins.

This medicine is given on a fixed schedule. It can be administered after taking ifosfamide, 4 hours and 8 hours after each ifosfamide dose.

Drink extra fluids (1 to 2 liters per day) to help you pass more urine while taking this medication. This can help prevent bladder and kidney problems.

Missed dose

This medicine must be administered on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Precautions when using Mesna

It is very important that your doctor closely monitors your progress while you are taking this medicine to make sure that this medicine is working properly. Blood and urine tests are required to check for adverse effects.

This medicine is used together with ifosfamide. Ifosfamide can harm your unborn baby during pregnancy. It can also cause birth defects if the father receives it while his sexual partner becomes pregnant. Use an effective form of contraception during treatment with this medicine in combination with ifosfamide and for 6 months after the last dose. Male patients with female partners should use an effective form of contraception during treatment and for 3 months after the last dose. If you think you have become pregnant while taking this medicine, tell your doctor immediately.

This medicine can cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. The most serious signs of this reaction are very rapid or irregular breathing, shortness of breath, or fainting. Other signs may include changes in facial skin color, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, and swelling or puffiness of the eyelids or around the eyes. If these side effects occur, get emergency help immediately.

Serious skin reactions can occur with this medicine. Contact your doctor immediately if you experience blistering, peeling or loosening of the skin, red skin lesions, severe acne or rash, sores or ulcers on the skin, or fever or chills while taking this medicine.

This medicine contains benzyl alcohol, which can cause serious reactions in premature or low birth weight babies. Talk to your doctor if you have any concerns about this.

Make sure any doctor or dentist who treats you knows that you are receiving this medicine. It can affect the results of certain medical tests.

Mesna side effects

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Contact your doctor or nurse immediately if any of the following side effects occur:

More common

• Schwarzer, teeriger Stuhl
• Zahnfleischbluten
• Blähungen oder Schwellungen im Gesicht, an Armen, Händen, Unterschenkeln oder Füßen
• Blut im Urin oder Stuhl
• Brustschmerzen
• Schüttelfrost
• Husten
• vermindertes Wasserlassen
• Schwindel
• trockener Mund
• Ohnmacht
• schneller, hämmernder oder unregelmäßiger Herzschlag oder Puls
• Fieber
• Erhöhter Durst
• Benommenheit
• Appetitverlust
• Stimmungsschwankungen
• Muskelschmerzen oder Krämpfe
• Brechreiz
• Taubheitsgefühl oder Kribbeln in den Händen, Füßen oder Lippen
• schmerzhaftes oder schwieriges Wasserlassen
• Punktgenaue rote Flecken auf der Haut
• schnelles Atmen
• schnelle Gewichtszunahme
• Anfälle
• Halsentzündung
• Wunden, Geschwüre oder weiße Flecken auf den Lippen oder im Mund
• eingefallene Augen
• Schwellung
• geschwollene Drüsen
• Engegefühl in der Brust
• Atembeschwerden
• ungewöhnliche Blutungen oder Blutergüsse
• ungewöhnliche Müdigkeit oder Schwäche
• ungewöhnliche Gewichtszunahme oder -abnahme
• Erbrechen
• faltige Haut

Less common

• Verschwommene Sicht
• Verwirrung
• Schwindel, Ohnmacht oder Benommenheit beim plötzlichen Aufstehen aus einer liegenden oder sitzenden Position
• Schwitzen

Incident not known

• Husten oder Blut spucken
• dunkler Urin
• allgemeine Müdigkeit und Schwäche
• Kopfschmerzen
• heller Stuhlgang
• Nervosität
• in den Ohren hämmern
• langsamer Herzschlag
• Schmerzen im oberen rechten Bauch oder Magen
• gelbe Augen und Haut

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Rückenschmerzen
• Blutungen, Blasenbildung, Brennen, Kälte, Verfärbung der Haut, Druckgefühl, Nesselsucht, Infektion, Entzündung, Juckreiz, Klumpen, Taubheitsgefühl, Schmerzen, Hautausschlag, Rötung, Narbenbildung, Schmerzen, Stechen, Schwellung, Empfindlichkeit, Kribbeln, Geschwürbildung oder Wärme an der Injektionsstelle
• Durchfall
• Schwierigkeiten beim Stuhlgang
• Haarausfall
• vermehrtes Schwitzen
• Mangel oder Verlust der Kraft
• Schläfrigkeit oder ungewöhnliche Schläfrigkeit
• Magenschmerzen
• Schlafstörungen
• Gewichtsverlust

Less common

• Aufstoßen
• Gefühl von Wärme
• Sodbrennen
• Verdauungsstörungen
• Rötung des Gesichts, des Halses, der Arme und gelegentlich der oberen Brust
• Magenbeschwerden oder Magenverstimmung

Incident not known

• Geschmacksveränderung oder Geschmacksverlust

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Mesnex

Available dosage forms:

• Lösung

Therapeutic class: Inhibitor of hemorrhagic cystitis

More information