Nexobrid (topical application)

Nexobrid (topical application)

Nexobrid (topical application)

Possible uses for Nexobrid

This medicine should only be administered by or under your doctor's direct supervision.

Before using Nexobrid

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

No appropriate studies have been conducted on the relationship between age and the effects of anacaulase-bcdb topical gel in children and adolescents. Safety and effectiveness have not been established.

geriatrics

Related studies conducted to date have not shown any geriatric-specific problems that would limit the usefulness of Anacaulase-bcdb topical gel in the elderly.

Breastfeeding

There are insufficient studies in women to determine the risk to infants when using this drug while breast-feeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. Tell your doctor if you are taking other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or around the time of eating or consuming certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. Discuss using your medicine with food, alcohol or tobacco with your doctor.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Allergie gegen Bromelain, Ananas, Papayas oder Papain – sollte bei Patienten mit dieser Erkrankung nicht angewendet werden.

• Blutungsprobleme bzw
• Blutgerinnungsprobleme, unkontrolliert oder
• Niedrige Thrombozytenzahl – Mit Vorsicht anwenden. Kann diese Bedingungen verschlimmern.

• Mit radioaktiven und gefährlichen Stoffen kontaminierte Wunden – die Anwendung wird bei Patienten mit dieser Erkrankung nicht empfohlen.

Correct use of Nexobrid

A nurse or other trained health professional will give you this medicine in a medical facility. It is only applied to the skin.

Your doctor may apply ointments to protect open wounds (e.g., cuts, abrasions, lacerations) before applying the gel.

Precautions when using Nexobrid

It is very important that your doctor monitor your progress closely to make sure this medicine is working properly and to check for any unwanted effects.

This medicine can cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Consult your doctor immediately if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching or rash, swelling or puffiness of the eyelids or around the eyes, face, lips, or tongue, difficulty breathing, or unusual tiredness or weakness.

Nexobrid side effects

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Contact your doctor or nurse immediately if any of the following side effects occur:

More common

• Blasse Haut
• Atembeschwerden
• ungewöhnliche Blutungen oder Blutergüsse
• ungewöhnliche Müdigkeit oder Schwäche

Less common

• Blasenschmerzen
• blutiger oder trüber Urin
• verschwommene Sicht
• Verwirrung
• Husten oder Heiserkeit
• schwieriges, brennendes oder schmerzhaftes Wasserlassen
• Schwindel, Ohnmacht oder Benommenheit beim plötzlichen Aufstehen aus einer liegenden oder sitzenden Position
• Augenschmerzen
• schneller, hämmernder oder unregelmäßiger Herzschlag oder Puls
• Fieber oder Schüttelfrost
• häufiger Harndrang
• allgemeines Krankheitsgefühl
• Kopfschmerzen
• Schmerzen im unteren Rücken oder an der Seite
• Halsentzündung
• Magenschmerzen
• Schwitzen

Incident not known

• Engegefühl in der Brust
• Schluckbeschwerden
• Nesselsucht, Juckreiz, Hautausschlag
• Schwellungen oder Schwellungen der Augenlider oder um die Augen, das Gesicht, die Lippen oder die Zunge

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Schlafstörungen
• Erbrechen

Less common

• Narbe

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Nexobrid

Available dosage forms:

• Gel/Gelee

Therapeutic class: Dermatological agent

Pharmacological class: Anacaulase

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