Estradiol and medroxyprogesterone (intramuscularly)

Estradiol and medroxyprogesterone (intramuscularly)

Estradiol and medroxyprogesterone (intramuscularly)

Uses for estradiol and medroxyprogesterone

This medicine is only available with a doctor's prescription.

Before using estradiol and medroxyprogesterone

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

This medicine can be used for contraception in teenage girls and is not expected to cause any side effects or problems other than those in adults. Some teenagers may need additional information about the importance of taking this medication exactly as prescribed.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are taking this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or to change some of the other medications you are taking.

• Tranexamsäure

Using this medicine with any of the following medicines is not usually recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Abametapir
• Amifampridin
• Amoxicillin
• Ampicillin
• Amprenavir
• Apalutamid
• Aprepitant
• Armodafinil
• Artemether
• Bacampicillin
• Belzutifan
• Betamethason
• Bexaroten
• Bosentan
• Bupropion
• Carbamazepin
• Carbenicillin
• Cefaclor
• Cefadroxil
• Cefdinir
• Cefditoren
• Cefixim
• Cefpodoxim
• Cefprozil
• Ceftazidim
• Ceftibuten
• Cefuroxim
• Cenobamat
• Ceritinib
• Clobazam
• Cloxacillin
• Colesevelam
• Conivaptan
• Cyclacillin
• Cyclosporin
• Dabrafenib
• Darunavir
• Dexamethason
• Dicloxacillin
• Donepezil
• Doxycyclin
• Efavirenz
• Elagolix
• Elvitegravir
• Encorafenib
• Enzalutamid
• Eslicarbazepinacetat
• Etravirin
• Fedratinib
• Fexinidazol
• Fosamprenavir
• Fosaprepitant
• Fosnetupitant
• Fosphenytoin
• Griseofulvin
• Guarkernmehl
• Isotretinoin
• Itraconazol
• Ivosidenib
• Lesinurad
• Lixisenatid
• Lorlatinib
• Lumacaftor
• Mavacamten
• Meropenem
• Minocyclin
• Mitapivat
• Mitotan
• Mobocertinib
• Modafinil
• Mycophenolatmofetil
• Mycophenolsäure
• Nafcillin
• Nelfinavir
• Netupitant
• Nevirapin
• Octreotid
• Oxacillin
• Oxcarbazepin
• Oxytetracyclin
• Penicillin G
• Penicillin G Procain
• Penicillin V
• Phenobarbital
• Phenylbutazon
• Phenytoin
• Pitolisant
• Pixantrone
• Prednisolon
• Prednison
• Primidon
• Rotklee
• Rifabutin
• Rifampin
• Rifapentin
• Ritonavir
• Rufinamid
• Secobarbital
• Somatrogon-ghla
• Johanniskraut
• Sugammadex
• Sultamicillin
• Tazemetostat
• Telaprevir
• Tetracyclin
• Theophyllin
• Ticarcillin
• Tigecyclin
• Tirzepatid
• Topiramat
• Ulipristal
• Valproinsäure

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but using both medicines may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Atazanavir
• Diazepam
• Ginseng
• Lamotrigin
• Levothyroxin
• Lakritze
• Lorazepam
• Selegilin
• Tacrin
• Temazepam
• Tipranavir
• Triazolam
• Troleandomycin
• Voriconazol
• Warfarin

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. The following interactions were selected for their potential significance and are not necessarily exhaustive.

Using this medicine with any of the following medicines may result in an increased risk of certain side effects, but may be unavoidable in some cases. If used together, your doctor may change the dose or frequency of use of this medication, or give you special instructions about food, alcohol, or tobacco consumption.

• Koffein

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Abnormale Veränderungen der Menstruations- oder Uterusblutung
• Blutgerinnsel (oder Vorgeschichte davon) oder
• Gallenblasenerkrankung oder Gallensteine ​​(oder Vorgeschichte davon) oder
• Herz- oder Kreislaufprobleme bzw
• Hoher Cholesterinspiegel im Blut bzw
• Hoher Blutdruck (Hypertonie) bzw
• Lebererkrankung (oder Vorgeschichte) oder
• Psychische Probleme – Kombinierte Verhütungsmittel können diese Erkrankungen verschlimmern oder in seltenen Fällen dazu führen, dass sie erneut auftreten.
• Krebs, einschließlich Brustkrebs – Verhütungsmittel können einige Krebsarten verschlimmern, insbesondere wenn bereits Brust-, Gebärmutterhals- oder Gebärmutterkrebs besteht. Die Verwendung monatlich injizierbarer Verhütungsmittel wird nicht empfohlen, wenn Sie unter einer dieser Erkrankungen leiden. Wenn in Ihrer Familie Brusterkrankungen aufgetreten sind, sind injizierbare Verhütungsmittel möglicherweise immer noch eine gute Wahl, aber Sie müssen sich möglicherweise häufiger testen lassen

• Diabetes mellitus (Zuckerdiabetes) – Die Anwendung kombinierter Verhütungsmittel kann zu einem Anstieg, normalerweise nur einem geringfügigen Anstieg Ihres Blutzuckers führen und hat normalerweise keinen Einfluss auf die Menge an Diabetesmedikamenten, die Sie einnehmen.
• Migränekopfschmerzen – Kombinierte Verhütungsmittel können zu Flüssigkeitsansammlungen führen und diese Beschwerden verschlimmern; Manche Menschen haben jedoch weniger Migränekopfschmerzen, wenn sie Verhütungsmittel anwenden

Proper use of estradiol and medroxyprogesterone

dosage

The dose of this medicine is different for different patients. Follow your doctor's instructions or the label directions. The following information includes average doses of this medicine only. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. In addition, the number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical problem for which you are using the medicine.

• Für die Injektionsdosisform:
  • Zur Empfängnisverhütung
    • Erwachsene – alle 28 bis 30 Tage werden 0,5 Milliliter (ml) in einen Muskel im Oberarm, Oberschenkel oder im Gesäß injiziert.

Missed dose

Call your doctor or pharmacist for instructions.

If you miss your next injection by day 33, your doctor will want to rule out pregnancy before giving you the medicine again. Another method of contraception should be used until your period starts or your doctor determines that you are not pregnant and you can take the medicine again.

Precautions when using estradiol and medroxyprogesterone

It is very important that your doctor check your progress at regular visits to make sure this medicine is not causing any unwanted effects. These physical exams usually take place every 12 months, but you will need to see your doctor every 28 to 30 days to receive your injection.

This medicine does not protect a woman from sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS).

Side effects of estradiol and medroxyprogesterone

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Consult your doctor immediately if any of the following side effects occur:

More common

• Blähungen oder Schwellungen im Gesicht, an den Händen, Unterschenkeln und/oder Füßen
• Husten
• Schluckbeschwerden
• Schwindel
• schneller Herzschlag
• Nesselsucht
• Juckreiz
• Appetitlosigkeit und Übelkeit
• Schwellungen oder Schwellungen der Augenlider oder um die Augen, das Gesicht, die Lippen oder die Zunge
• schnelle Gewichtszunahme
• Kurzatmigkeit
• Engegefühl in der Brust
• ungewöhnliche Müdigkeit oder Schwäche
• Blut erbrechen
• keuchend
• gelbe Augen oder Haut

Symptoms of overdose – more common

• Brechreiz
• Menstruationsunregelmäßigkeiten
• vaginale Blutung
• Erbrechen

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Bauchschmerzen oder vergrößerter Bauch
• fehlende oder versäumte Menstruationsperioden
• Akne
• allergischer Ausschlag
• braune, fleckige Flecken auf der Haut
• verminderter Sexualtrieb
• Depression
• Haarausfall/Haarausfall
• Kopfschmerzen
• vermehrte Menstruationsblutung oder normale Blutung, die früher auftritt
• Mangel oder Verlust der Kraft

• Nervosität
• schnell reagieren oder emotional übertreiben
• schnell wechselnde Stimmungen
• Stoppen der Menstruationsblutung über mehrere Monate
• Scheidenpilzinfektion
• Gewichtsänderung

Commonly used brand names

In the USA

• Lunelle Monatsverhütungsmittel

Pharmacological class: Medroxyprogesterone

More information