Rimegepant

Rimegepant

Rimegepant

What is rimegepant?

Rimegepant is an orally disintegrating tablet (ODT) that dissolves in the mouth without the need to be taken with a glass of water. Because the tablet dissolves in the mouth, it is quickly absorbed into the bloodstream, with peak blood concentrations reached after one and a half hours.

Warnings

It is not known whether it is safe to take Rimegepant ODT for more than 15 migraine headaches within 30 days.

Rimegepant ODT can be taken once daily as needed. You should not take more than 1 tablet in 24 hours.

Follow all instructions on the label and packaging of your medicine. Tell each of your healthcare providers about all your medical conditions, allergies and any medications you take.

If you take too much Rimegepant ODT, go to the nearest emergency room immediately.

Before you take this medicine

You should not use rimegepant if you are allergic to it.

To make sure rimegepant is safe for you, tell your doctor if you have ever had:

• liver disease; or

• Kidney disease (or if you are on dialysis).

It is not known whether rimegepant will harm an unborn baby. However, migraine headaches can lead to complications during pregnancy, such as dangerously high blood pressure, which can lead to medical problems for both mother and baby. The benefits of migraine treatment may outweigh the risks to the baby.

Breastfeeding may not be safe while using this medication. Ask your doctor about any risks.

Rimegepant is not approved for use by people under 18 years of age.

How should I take Rimegepant?

Use Rimegepant ODT exactly as your doctor has told you. Follow all instructions on your prescription label and read any medication guides or instructions for use.

Call your doctor if your symptoms do not improve or if you have more than 15 headaches in a month (30 days).

Do not remove an orally disintegrating tablet from the package until you are ready to take the medicine.

• Use dry hands when opening the blister pack.

• Peel off the foil cover of a blister pack and carefully remove the orally disintegrating tablet (ODT). Do not force the ODT through the foil.

• Once the blister pack is opened, remove the ODT and place it on the tongue. Alternatively, the ODT can also be placed under the tongue.

• The ODT breaks down in saliva so it can be swallowed without additional liquid.

• Swallow several times while the tablet dissolves.

• Take ODT immediately after opening the blister pack. Do not store the ODT outside the blister pack for later use.

Store at cool room temperature, away from moisture and heat.

Dosage information

Usual adult dosage for migraines:

75 mg orally
Maximum dose: 75 mg in a 24 hour period

Comments:
-This medication is not intended for the preventive treatment of migraines.
-The safety of treating more than 15 migraine attacks in a 30-day period is not known.

Application: For the acute treatment of migraines with or without aura.

Place on the tongue (or under the tongue), let it dissolve in saliva and swallow; additional fluid is not necessary. Do not take more than one dose in 24 hours.

What happens if I miss a dose?

Because rimegepant is used as needed, there is no daily dosing schedule. Call your doctor if your symptoms do not improve after using this medication.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help hotline at 1-800-222-1222.

What to avoid

Follow your doctor's instructions regarding any food, drink, or activity restrictions.

Rimegepant side effects

If necessary, get emergency medical helpSigns of an allergic reaction to rimegepant:hives, rash; difficult breathing; Swelling of your face, lips, tongue, or throat.

An allergic reaction may be serious and may occur days after taking this medication.

Common side effects of rimegepant may include nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect rimegepant?

Sometimes it is not safe to take certain medications at the same time. Some medications can affect the blood levels of other medications you are taking, which may increase side effects or make the medications less effective.

If you are taking any of the following medicines, avoid taking rimegepant within 48 hours of the last time you took the other medicine:

• aprepitant;

• erythromycin;

• fluconazole; or

• Heart or blood pressure medications– Diltiazem, verapamil.

This list is not complete and many other medications may interact with rimegepant. This includes prescription and over-the-counter medications, vitamins and herbal products. Not all possible drug interactions are listed here.