Thrombocytosis

Thrombocytosis

overview

Platelets are blood particles produced in the bone marrow that play an important role in the formation of blood clots. Thrombocytosis (throm-boe-sie-TOE-sis) is a condition in which your body produces too many platelets.

It is called reactive thrombocytosis or secondary thrombocytosis when the cause is an underlying condition such as an infection.

Less commonly, when thrombocytosis has no obvious underlying disease as its cause, the disorder is called primary thrombocythemia or essential thrombocythemia. This is a blood and bone marrow disease.

Your doctor may detect thrombocytosis in a routine blood test result that shows high levels of platelets. If your blood test indicates thrombocytosis, it is important to determine whether it is reactive thrombocytosis or essential thrombocythemia in order to know how to manage the condition.

Types

1. Essential thrombocythemia

Symptoms

People with thrombocytosis often have no signs or symptoms. Signs and symptoms of reactive thrombocytosis, if they occur, are related to the underlying disease.

People with essential thrombocythemia may have signs and symptoms related to blood clots and bleeding, including:

• Kopfschmerzen
• Schwindel oder Benommenheit
• Brustschmerzen
• Die Schwäche
• Taubheit oder Kribbeln der Hände und Füße

When to go to the doctor?

Because thrombocytosis is unlikely to cause any symptoms, you probably won't know you have it unless a routine blood test shows a higher than normal number of platelets. If this occurs, your doctor will try to determine the cause.

Causes

Bone marrow – spongy tissue in your bones – contains stem cells that can become red blood cells, white blood cells, or platelets. Platelets stick together and help the blood form a clot that stops bleeding when you injure a blood vessel, such as in a blood vessel. B. if you cut yourself. Thrombocytosis occurs when your body produces too many platelets.

Reactive thrombocytosis

This is the more common form of thrombocytosis. It is caused by an underlying medical problem, such as:

• Akute Blutungen und Blutverlust
• Krebs
• Infektionen
• Eisenmangel
• Entfernung Ihrer Milz
• Hämolytische Anämie – eine Art von Anämie, bei der Ihr Körper rote Blutkörperchen schneller zerstört als sie produziert, oft aufgrund bestimmter Blutkrankheiten oder Autoimmunerkrankungen
• Entzündliche Erkrankungen wie rheumatoide Arthritis, Sarkoidose oder entzündliche Darmerkrankungen
• Operation oder andere Art von Trauma

Essential thrombocythemia

The cause of this disorder is unclear, but often appears to be linked to mutations in a variety of genes. Your bone marrow produces too many of the cells that make platelets, and these platelets are often abnormal. This carries a much higher risk of clotting or bleeding complications than reactive thrombocytosis.

Thrombocytosis treatment

Sources:

1. Tefferi A. Annäherung an den Patienten mit Thrombozytose. https://www.uptodate.com/contents/search. Abgerufen am 31. Juli 2018.
2. Thrombozythämie und Thrombozytose. Nationales Institut für Herz, Lunge und Blut. https://www.nhlbi.nih.gov/health-topics/thrombocythemia-and-thrombocytosis. Abgerufen am 31. Juli 2018.
3. Fragen Sie MayoExpert. Essentielle Thrombozythämie (Erwachsener). Rochester, Minnesota: Mayo Foundation for Medical Education and Research; 2017.
4. Reaktive Thrombozytose (sekundäre Thrombozythämie). Merck Manual Professional-Version. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/reactive-thrombocytosis-secondary-thrombocythemia. Abgerufen am 31. Juli 2018.
5. Tefferi A. Diagnose und klinische Manifestationen der essentiellen Thrombozythämie. https://www.uptodate.com/contents/search. Abgerufen am 31. Juli 2018.
6. Morgen ES. Allscripts EPSi. Mayo Clinic, Rochester, Minnesota, 2. April 2018.

1. Essential thrombocythemia