Tussiclear DH (oral)

Tussiclear DH (oral)

Tussiclear DH (oral) Oral route (solution)

Warning: Addiction, Abuse and Abuse; Life-threatening respiratory depression, accidental ingestion, medication errors; cytochrome P450 3A4 interaction; Concomitant use with benzodiazepines or other CNS depressants; interaction with alcohol; Opioid withdrawal syndrome in newborns

Hydrocodone bitartrate/guaifenesin exposes users to the risk of addiction, abuse, and misuse, which may result in overdose and death. Assess the patient's risk prior to prescribing and closely monitor these behaviors and conditions.

Severe, life-threatening or fatal respiratory depression may occur. Monitor use carefully, particularly initially or when used in patients at higher risk.

Accidental ingestion of hydrocodone bitartrate/guaifenesin, especially by children, can result in a fatal hydrocodone overdose

Ensure accuracy when prescribing, dispensing, and administering hydrocodone bitartrate/guaifenesin. Dosing errors can result in accidental overdose and death.

Concurrent use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) may result in fatal hydrocodone overdose. Avoid use of hydrocodone bitartrate/guaifenesin in patients taking CYP3A4 inhibitors or inducers.

Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may cause profound sedation, respiratory depression, coma, and death. Avoid use of hydrocodone bitartrate/guaifenesin in patients taking benzodiazepines, other CNS depressants, or alcohol.

Advise patients not to consume alcohol or alcohol-containing products while taking hydrocodone bitartrate/guaifenesin as concurrent use may result in fatal plasma levels of hydrocodone.

The use of hydrocodone bitartrate/guaifenesin in pregnant women is not recommended. Prolonged use of hydrocodone bitartrate/guaifenesin during pregnancy may result in neonatal opioid withdrawal syndrome, which can be life-threatening if not recognized and treated. If hydrocodone bitartrate/guaifenesin is used long-term in a pregnant woman, inform the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment is available.

Oral route (tablet)

Addiction, Abuse and Abuse:

Hydrocodone bitartrate and guaifenesin tablets expose patients and other users to the risk of opioid dependence, opioid abuse, and misuse, which may result in overdose and death. Reserve hydrocodone bitartrate and guaifenesin tablets for use in adult patients in whom the benefits of cough suppression are expected to outweigh the risks and in whom an appropriate assessment of cough etiology has been made. Assess each patient's risk prior to prescribing hydrocodone bitartrate and guaifenesin tablets, prescribe hydrocodone bitartrate and guaifenesin tablets for the shortest duration consistent with the patient's individual treatment goals, monitor all patients regularly for the development of admixture or abuse, and only re-evaluate the need for further treatment.

Life-threatening respiratory depression:

Severe, life-threatening, or fatal respiratory depression may occur with use of hydrocodone bitartrate and guaifenesin tablets. Monitor for respiratory depression particularly when initiating hydrocodone bitartrate and guaifenesin tablets or when used in patients at higher risk.

Accidental ingestion:

Accidental ingestion of even one dose of hydrocodone bitartrate and guaifenesin tablets, especially by children, can result in a fatal hydrocodone overdose.

Risk of medication errors

Maintain accuracy when prescribing, dispensing, and administering hydrocodone bitartrate and guaifenesin tablets. Dosing errors can result in accidental overdose and death.

Cytochrome P450 3A4 Interaction:

Concomitant use of hydrocodone bitartrate and guaifenesin tablets with any cytochrome P450 3A4 inhibitors may result in increased hydrocodone plasma concentrations, which may increase or prolong adverse drug reactions and potentially cause fatal respiratory depression. Additionally, discontinuation of a concurrent cytochrome P450 3A4 inducer may result in an increase in hydrocodone plasma concentrations. Avoid use of hydrocodone bitartrate and guaifenesin tablets in patients taking a CYP3A4 inhibitor or inducer.

Risks when used concurrently with benzodiazepines or other CNS depressants:

Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may cause profound sedation, respiratory depression, coma, and death. Avoid use of hydrocodone bitartrate and guaifenesin tablets in patients taking benzodiazepines, other CNS depressants, or alcohol.

Interaction with alcohol:

Advise patients not to consume alcoholic beverages or use any prescription or nonprescription products that contain alcohol while taking hydrocodone bitartrate and guaifenesin tablets. Concomitant use of alcohol with hydrocodone bitartrate and guaifenesin tablets may result in increased plasma levels and a potentially fatal overdose of hydrocodone.

Neonatal opioid withdrawal syndrome:

The use of hydrocodone bitartrate and guaifenesin tablets in pregnant women is not recommended. Prolonged use of hydrocodone bitartrate and guaifenesin tablets during pregnancy may result in neonatal opioid withdrawal syndrome, which can be life-threatening if not recognized and treated and requires treatment according to protocols developed by neonatology experts. If hydrocodone bitartrate and guaifenesin tablets are used for an extended period of time in a pregnant woman, inform the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment is available

Uses for Tussiclear DH

Hydrocodone is a narcotic antitussive (cough suppressant). It acts directly on the cough center in the brain and relieves coughs. Guaifenesin is used to clear mucus or phlegm from the chest when you have congestion due to a cold or flu. It works by thinning the mucus or phlegm in the lungs.

This medicine is only available with a doctor's prescription.

Before using Tussiclear DH

When deciding whether to use a medicine, the risks of taking the medicine must be weighed against the benefits it produces. This is a decision that you and your doctor will make. The following should be noted with this medicine:

Allergies

Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also tell your doctor if you have other allergies, such as to foods, dyes, preservatives or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatrics

The use of hydrocodone in children under 6 years of age has caused serious breathing problems, sometimes leading to death. No appropriate studies have been conducted on the relationship between age and the effects of the combination of guaifenesin and hydrocodone in children and adolescents. Safety and effectiveness have not been established.

geriatrics

Studies conducted to date have not shown any geriatric-specific problems that would limit the benefit of the combination of guaifenesin and hydrocodone in the elderly. However, older patients are at higher risk of developing age-related kidney, liver, or heart problems, which may require caution and dose adjustment in patients receiving this drug.

Breastfeeding

There are insufficient studies in women to determine the risk to infants when using this drug while breast-feeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug interactions

Although certain medicines should not be used together at all, in other cases two different medicines can be used together, although interactions may occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. If you are taking this medicine, it is particularly important that your doctor knows whether you are taking any of the medicines listed below. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or to change some of the other medications you are taking.

• Nalmefen
• Naltrexon
• Safinamid
• Samidorphan

Using this medicine with any of the following medicines is not usually recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

• Abametapir
• Acepromazin
• Alfentanil
• Almotriptan
• Alprazolam
• Amifampridin
• Amineptin
• Amiodaron
• Amitriptylin
• Amitriptylinoxid
• Amobarbital
• Amoxapin
• Amphetamin
• Amprenavir
• Anileridin
• Aprepitant
• Aripiprazol
• Armodafinil
• Asenapin
• Atazanavir
• Baclofen
• Benperidol
• Benzphetamin
• Boceprevir
• Bosentan
• Bromazepam
• Bromoprid
• Brompheniramin
• Buprenorphin
• Bupropion
• Buspiron
• Butabarbital
• Butorphanol
• Calciumoxybat
• Cannabidiol
• Cannabis
• Carbamazepin
• Carbinoxamin
• Carisoprodol
• Carphenazin
• Ceritinib
• Cetirizin
• Chloralhydrat
• Chlordiazepoxid
• Chlorpheniramin
• Chlorpromazin
• Chlorzoxazon
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clobazam
• Clomipramin
• Clonazepam
• Clopidogrel
• Clorazepat
• Clozapin
• Cobicistat
• Kokain
• Kodein
• Conivaptan
• Crizotinib
• Cyclobenzaprin
• Cyclosporin
• Daridorexant
• Darunavir
• Dasabuvir
• Delavirdin
• Desipramin
• Desmopressin
• Desvenlafaxin
• Dexamethason
• Dexmedetomidin
• Dextroamphetamin
• Dextromethorphan
• Dezocine
• Diazepam
• Dibenzepin
• Dichloralphenazon
• Difenoxin
• Dihydrocodein
• Diltiazem
• Diphenhydramin
• Diphenoxylat
• Dolasetron
• Donepezil
• Doxepin
• Doxylamin
• Dronedaron
• Droperidol
• Duloxetin
• Efavirenz
• Eletriptan
• Enfluran
• Enzalutamid
• Erythromycin
• Escitalopram
• Esketamin
• Eslicarbazepinacetat
• Estazolam
• Eszopiclon
• Ethchlorvinyl
• Ethopropazin
• Ethylmorphin
• Etravirin
• Fedratinib
• Fenfluramin
• Fentanyl
• Fexinidazol
• Flibanserin
• Fluconazol
• Fluoxetin
• Fluphenazin
• Flurazepam
• Fluspirilene
• Fluvoxamin
• Fosamprenavir
• Fosaprepitant
• Fosnetupitant
• Fosphenytoin
• Fospropofol
• Frovatriptan
• Furazolidon
• Gabapentin
• Gabapentin Enacarbil
• Gepiron
• Granisetron
• Halazepam
• Haloperidol
• Halothan
• Hexobarbital
• Hydromorphon
• Hydroxytryptophan
• Hydroxyzin
• Idelalisib
• Imatinib
• Imipramin
• Indinavir
• Iproniazid
• Isocarboxazid
• Isofluran
• Itraconazol
• Ivacaftor
• Ketamin
• Ketazolam
• Ketobemidon
• Ketoconazol
• Lacosamid
• Lasmiditan
• Lemborexant
• Lenacapavir
• Levocetirizin
• Levomilnacipran
• Levorphanol
• Linezolid
• Lisdexamfetamin
• Lithium
• Lofepramin
• Lofexidin
• Lomitapid
• Lopinavir
• Lorazepam
• Lorcaserin
• Loxapin
• Lumacaftor
• Magnesiumoxybat
• Mavacamten
• Meclizin
• Melitracen
• Melperon
• Meperidin
• Mephobarbital
• Meprobamat
• Meptazinol
• Mesoridazin
• Metaxalone
• Methadon
• Methamphetamin
• Methdilazin
• Methocarbamol
• Methohexital
• Methotrimeprazin
• Methylenblau
• Metoclopramid
• Mibefradil
• Midazolam
• Mifepriston
• Milnacipran
• Mirtazapin
• Mitotan
• Moclobemid
• Modafinil
• Molindon
• Moricizin
• Morphium
• Morphinsulfat-Liposom
• Nafcillin
• Nalbuphin
• Naratriptan
• Nefazodon
• Nelfinavir
• Netupitant
• Nevirapin
• Nialamid
• Nicomorphin
• Nilotinib
• Nitrazepam
• Lachgas
• Nortriptylin
• Olanzapin
• Omaveloxolon
• Ombitasvir
• Ondansetron
• Opipramol
• Opium
• Opiumalkaloide
• Orphenadrin
• Oxazepam
• Oxcarbazepin
• Oxycodon
• Oxymorphon
• Ozanimod
• Palbociclib
• Palonosetron
• Papaveretum
• Paregorisch
• Paritaprevir
• Paroxetin
• Pentazocin
• Pentobarbital
• Perampanel
• Perazin
• Periciazin
• Perphenazin
• Phenelzin
• Phenobarbital
• Phenytoin
• Piperacetazin
• Pipotiazin
• Piritramid
• Posaconazol
• Kaliumoxybat
• Prazepam
• Prednison
• Pregabalin
• Primidon
• Procarbazin
• Prochlorperazin
• Promazin
• Promethazin
• Propofol
• Protriptylin
• Quazepam
• Quetiapin
• Ramelteon
• Ranitidin
• Ranolazin
• Rasagilin
• Remifentanil
• Remimazolam
• Remoxiprid
• Rifabutin
• Rifampin
• Rifapentin
• Ritonavir
• Rizatriptan
• Ropeginterferon Alfa-2b-njft
• Saquinavir
• Scopolamin
• Secobarbital
• Selegilin
• Sertindol
• Sertralin
• Sibutramin
• Natriumoxybat
• Johanniskraut
• Sufentanil
• Sulpirid
• Sumatriptan
• Suvorexant
• Tapentadol
• Telaprevir
• Telithromycin
• Temazepam
• Thiethylperazin
• Thiopental
• Thiopropazat
• Thioridazin
• Tianeptin
• Tilidin
• Tizanidin
• Toloniumchlorid
• Topiramat
• Tramadol
• Tranylcypromin
• Trazodon
• Triazolam
• Trifluoperazin
• Trifluperidol
• Triflupromazin
• Trimeprazin
• Trimipramin
• Tryptophan
• Venlafaxin
• Verapamil
• Vilazodon
• Voriconazol
• Vortioxetin
• Zaleplon
• Ziprasidon
• Zolmitriptan
• Zolpidem
• Zopiclon
• Zotepin
• Zuranolon

Interactions with food/tobacco/alcohol

Certain medicines should not be taken during or near food or consumption of certain foods because interactions may occur. Consuming alcohol or tobacco with certain medications can also lead to interactions. The following interactions were selected for their potential significance and are not necessarily exhaustive.

The use of this medicine for any of the following conditions is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or frequency of use of this medication, or give you special instructions about food, alcohol, or tobacco consumption.

• Ethanol
• Grapefruitsaft

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

• Akute Pankreatitis (Schwellung der Bauchspeicheldrüse) oder
• Addison-Krankheit (Nebennierenproblem) oder
• Alkoholmissbrauch oder Vorgeschichte von oder
• Hirntumor, Vorgeschichte von oder
• Atemprobleme, schwerwiegend (z. B. Hypoxie, Hyperkapnie) oder
• Chronisch obstruktive Lungenerkrankung (COPD) oder
• ZNS-Depression oder
• Cor pulmonale (schwere Herzerkrankung) oder
• Diabetes bzw
• Drogenmissbrauch oder -abhängigkeit, insbesondere von Betäubungsmitteln, oder Vorgeschichte von oder
• Vergrößerte Prostata bzw
• Gallenblasenerkrankung bzw
• Kopfverletzungen bzw
• Erhöhter Druck im Kopf bzw
• Psychische Gesundheitsprobleme, Vorgeschichte von oder
• Magenprobleme bzw
• Schilddrüsenprobleme bzw
• Probleme beim Wasserlassen – mit Vorsicht anwenden. Kann das Risiko schwerwiegenderer Nebenwirkungen erhöhen.

• Asthma, akut oder schwer oder
• Husten, chronisch oder anhaltend oder
• Paralytischer Ileus (Darm funktioniert nicht mehr und kann verstopft sein), bekannt oder vermutet oder
• Atemdepression (sehr langsame Atmung) – Sollte bei Patienten mit diesen Erkrankungen nicht angewendet werden.

• Hypotonie (niedriger Blutdruck) – Mit Vorsicht anwenden. Kann diesen Zustand verschlimmern.

• Nierenerkrankung, schwere oder
• Lebererkrankung, schwer – mit Vorsicht anwenden. Kann diese Bedingungen verschlimmern.

Proper use of Tussiclear DH

Only take this medicine as directed by your doctor. Do not take more of it, do not take it more often, or take it for longer than your doctor prescribed. Taking too much of this medicine over a long period of time may cause habit-forming (leading to mental or physical dependence) or overdose.

This medicine should be accompanied by a medication guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Measure the oral fluid correctly using the marked measuring spoon, oral syringe, or medicine cup. The average teaspoon in the home may not hold the right amount of liquid. Ask your pharmacist for instructions on measuring the correct dose of this medicine.

dosage

The dose of this medicine is different for different patients. Follow your doctor's instructions or the label directions. The following information includes average doses of this medicine only. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. In addition, the number of doses you take each day, the time between doses, and how long you take the medicine depend on the medical problem for which you are using the medicine.

• Zur Linderung von Husten, Niesen, laufender oder verstopfter Nase:
  • Für orale Darreichungsform (Lösung):
    • Erwachsene – 10 Milliliter (ml) alle 4 bis 6 Stunden nach Bedarf. Nehmen Sie nicht mehr als 6 Dosen (60 ml) innerhalb von 24 Stunden ein.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.
  • Für orale Darreichungsform (Tabletten):
    • Erwachsene: 1 Tablette alle 4 bis 6 Stunden. Nehmen Sie nicht mehr als 6 Tabletten innerhalb von 24 Stunden ein.
    • Kinder – Anwendung und Dosis müssen von Ihrem Arzt festgelegt werden.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.

storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Protect from freezing.

Keep away from children.

Do not keep medications that are outdated or no longer needed.

Return unused narcotics immediately to a drug collection point. If you don't have a drug take-back location near you, flush unused narcotics down the toilet. Check with your local drugstore and clinic for take-back locations. You can also search for locations on the DEA website. Here is the link to the FDA website on safe drug disposal: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

Precautions when using Tussiclear DH

It is very important that your doctor checks your progress while using this medicine. This will help your doctor determine whether the medicine is working properly and decide whether you should continue taking it. If your symptoms don't improve or get worse, call your doctor.

Using your medicine is illegal and dangerous to others. Store unused liquids or oral tablets in a safe place. People who are addicted to drugs may want to steal this drug.

Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil® or Parnate® within the last 14 days.

This medicine can be habit forming. If you feel that the medicine is not working as well, do not take more than the prescribed dose. Call your doctor for instructions.

If you think you or someone else may have taken an overdose of this medicine, get emergency help immediately. Signs of overdose include dark urine, difficult or labored breathing, irregular, fast or slow or shallow breathing, nausea or vomiting, pain in the upper abdomen, pale or blue lips, fingernails or skin, pinpoint pupils of the eyes, etc. Yellow eyes or skin.

This medicine may cause dizziness or sleepiness. Do not drive or do other dangerous activities until you know how this medicine affects you.

This medicine increases the effects of alcohol and other CNS depressants (medicines that can make you sleepy or less alert). Some examples of CNS depressants include antihistamines or allergy or cold medications, sedatives, sedatives or sleep aids, other prescription painkillers or narcotics, antiseizure medications or barbiturates, muscle relaxants or anesthetics, including some dental anesthetics. Consult your doctor before taking any of these medicines while using this medicine.

Taking this medication may cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink plenty of fluids, or increase the amount of fiber in your diet. Be sure to follow the instructions carefully as persistent constipation can lead to more serious problems.

Dizziness, lightheadedness, or fainting may occur if you suddenly stand up from lying or sitting. Getting up slowly can help alleviate this problem. Lying down for a long time can also relieve the feeling of dizziness or lightheadedness.

Using this drug during pregnancy may cause serious adverse effects, including neonatal opioid withdrawal syndrome in your newborn. Tell your doctor immediately if you think you may be pregnant or plan to become pregnant while using this medication.

This medicine can cause adrenal insufficiency. Contact your doctor immediately if you experience darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, depression, nausea, rash, unusual tiredness or weakness, or vomiting.

If you have been using this medicine regularly for several weeks or longer, do not suddenly stop using it without consulting your doctor first. Your doctor may want you to gradually reduce the amount you take before stopping it completely. This can help reduce the possibility of withdrawal symptoms such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or difficulty sleeping.

Contact your doctor immediately if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle cramps, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Using too much of this medicine may cause infertility (inability to have children). If you plan to have children, talk to your doctor before taking the tablet.

Do not take any other medicines unless you have discussed this with your doctor. This includes both prescription and nonprescription (over-the-counter [OTC]) medications and herbal or vitamin supplements.

Side effects of Tussiclear DH

In addition to the necessary effects, a medicine may also have some undesirable effects. Although not all of these side effects may occur, medical attention may be required if they occur.

Consult your doctor immediately if any of the following side effects occur:

Incident not known

• Agitation
• Blasenschmerzen
• Blähungen oder Schwellungen im Gesicht, an Armen, Händen, Unterschenkeln oder Füßen
• blutiger oder trüber Urin
• Veränderungen im Sehvermögen
• Schüttelfrost
• Husten
• Verdunkelung der Haut
• Durchfall
• schwieriges, brennendes oder schmerzhaftes Wasserlassen
• Schwierigkeiten beim Schlucken oder Atmen
• Schwindel
• Schwindel, Ohnmacht oder Benommenheit beim plötzlichen Aufstehen aus der Liege- oder Sitzposition
• Ohnmacht
• schneller Herzschlag
• häufiger Harndrang
• Nesselsucht, Juckreiz, Hautausschlag
• unregelmäßige, schnelle oder langsame oder flache Atmung
• Appetitverlust
• Bewusstlosigkeit
• mentale Depression
• Brechreiz
• überaktive Reflexe
• Schmerzen im Magen, in der Seite oder im Unterleib, möglicherweise mit Ausstrahlung in den Rücken
• blasse oder blaue Lippen, Fingernägel oder Haut
• schlechte Koordination
• Schwellungen oder Schwellungen der Augenlider oder um die Augen, das Gesicht, die Lippen oder die Zunge
• schnelle Gewichtszunahme
• Ruhelosigkeit, Zittern, unkontrollierbares Sprechen oder Handeln mit Aufregung
• Engegefühl in der Brust
• Kribbeln der Hände oder Füße
• Zittern oder zitterndes Zucken
• ungewöhnliche Gewichtszunahme oder -abnahme
• Erbrechen
• gelbe Augen oder Haut

Some side effects may occur that usually do not require medical attention. These side effects may disappear during treatment as your body gets used to the medicine. Your doctor may also be able to give you ways to prevent or reduce some of these side effects. If any of the following side effects persist or are bothersome, or if you have any questions, contact your doctor:

More common

• Durchfall
• Schwierigkeiten beim Stuhlgang
• Gefühl von Wärme
• Kopfschmerzen
• Mangel oder Verlust der Kraft
• Brechreiz
• Rötung des Gesichts, des Halses, der Arme und gelegentlich der oberen Brust
• Schläfrigkeit oder ungewöhnliche Schläfrigkeit
• Magenschmerzen
• plötzliches Schwitzen
• Schlafstörungen

Some patients may also experience other side effects not listed. If you notice other side effects, contact your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Commonly used brand names

In the USA

• Canges-XP
• CodiClear DH
• ExeClear
• ExeCof XP
• Extendryl HC
• FluTuss XP
• Hydro-Tussin HG
• Monte-G HC
• Narcof
• Pancof XP
• Tussiclear DH
• Tusso-HC

Available dosage forms:

• Lösung

Therapeutic Class: Antitussive, Opioid/Expectorant

Chemical Class: Hydrocodone

More information