Expansion of the therapeutic toolbox for affective disorders with psychotropic drugs

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There is a need for new, effective treatments for mental illnesses such as depression and anxiety. Researchers are expanding the field's therapeutic toolbox by studying the antidepressant and anxiolytic properties of drugs like psilocybin and cannabis. The findings were presented at Neuroscience 2022, the annual meeting of the Society for Neuroscience and the world's largest source of breaking brain research and health news. Mental disorders are among the most frequently diagnosed mental illnesses worldwide. Current drug treatments for these disorders, such as serotonin modulators and benzodiazepines, are slow to work, and when they do, they often result in unwanted side effects. Furthermore speaking…

Es besteht ein Bedarf an neuen, wirksamen Behandlungen für psychische Erkrankungen wie Depressionen und Angstzustände. Forscher erweitern den therapeutischen Werkzeugkasten des Feldes, indem sie die antidepressiven und anxiolytischen Eigenschaften von Medikamenten wie Psilocybin und Cannabis untersuchen. Die Ergebnisse wurden auf der Neuroscience 2022 vorgestellt, dem Jahrestreffen der Society for Neuroscience und der weltweit größten Quelle für neue Nachrichten über Hirnforschung und Gesundheit. Psychische Störungen gehören weltweit zu den am häufigsten diagnostizierten psychischen Erkrankungen. Gegenwärtige medikamentöse Behandlungen für diese Störungen, wie Serotonin-Modulatoren und Benzodiazepine, wirken nur langsam, und wenn sie dies tun, führen sie oft zu unerwünschten Nebenwirkungen. Darüber hinaus sprechen …
There is a need for new, effective treatments for mental illnesses such as depression and anxiety. Researchers are expanding the field's therapeutic toolbox by studying the antidepressant and anxiolytic properties of drugs like psilocybin and cannabis. The findings were presented at Neuroscience 2022, the annual meeting of the Society for Neuroscience and the world's largest source of breaking brain research and health news. Mental disorders are among the most frequently diagnosed mental illnesses worldwide. Current drug treatments for these disorders, such as serotonin modulators and benzodiazepines, are slow to work, and when they do, they often result in unwanted side effects. Furthermore speaking…

Expansion of the therapeutic toolbox for affective disorders with psychotropic drugs

There is a need for new, effective treatments for mental illnesses such as depression and anxiety. Researchers are expanding the field's therapeutic toolbox by studying the antidepressant and anxiolytic properties of drugs like psilocybin and cannabis. The findings were presented at Neuroscience 2022, the annual meeting of the Society for Neuroscience and the world's largest source of breaking brain research and health news.

Mental disorders are among the most frequently diagnosed mental illnesses worldwide. Current drug treatments for these disorders, such as serotonin modulators and benzodiazepines, are slow to work, and when they do, they often result in unwanted side effects. Additionally, many people with depression do not respond to these medications at all. However, treatments derived from the psychedelic compound psilocybin and the psychoactive drug cannabis may hold promise for a range of mental disorders. Neuroscientists study how they function in the brain.

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Today's new findings show that:

  • Die bewusstseinsverändernden Wirkungen von Psilocybin sind möglicherweise nicht notwendig, um bei Mäusen angstlösende und antidepressive Wirkungen hervorzurufen. (Katherine M. Nautiyal, Dartmouth College)
  • Bei männlichen Ratten können die Symptome von Depression und Angst nach chronischem Stress durch die Verabreichung eines Proteins im Endocannabinoid-System des Gehirns verbessert werden. (Steven R. Laviolette, University of Western Ontario)
  • Chronischer Cannabiskonsum ist mit einer Verbesserung einiger kognitiver Funktionen bei Menschen mit bipolarer Störung verbunden. (Alannah Miranda, Universität von Kalifornien, San Diego)

“As a field, we are thinking about psilocybin and cannabis in new ways, evaluating them not only for their potential therapeutic benefits, but also studying how they exert their effects in the brain,” says Lisa Monteggia, Barlow Family Director of the Vanderbilt Brain Institute and professor of pharmacology at Vanderbilt University, who studies mechanisms underlying the effectiveness of antidepressants. “The research presented today adds to the growing evidence that these compounds may offer new pathways to symptom relief in many mental health conditions.”

This research was supported by national funding agencies including the National Institutes of Health and private funding organizations. Learn more about social behavior and the brain at BrainFacts.org.

Source:

Society for Neuroscience

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