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The nanoemulsion form of vitamin D3 could improve the core manifestations of autism
This study examines the effectiveness of a vitamin D3-loaded nanoemulsion in improving core symptoms of autism spectrum disorder (ASD) in children. Children with ASD often have low vitamin D3 levels, which are associated with delays in language development, adaptive behavior, and fine motor skills. While traditional vitamin D3 supplementation has shown mixed results in previous studies, this research evaluates whether a nanoemulsion form that improves absorption and enhances absorption and bioavailability might produce better results. Eighty children between 3 and 6 years of age diagnosed with ASD were randomly assigned into two groups: one received the vitamin D3 nanoemulsion and the...
The nanoemulsion form of vitamin D3 could improve the core manifestations of autism
This study examines the effectiveness of a vitamin D3-loaded nanoemulsion in improving core symptoms of autism spectrum disorder (ASD) in children. Children with ASD often have low vitamin D3 levels, which are associated with delays in language development, adaptive behavior, and fine motor skills. While traditional vitamin D3 supplementation has shown mixed results in previous studies, this research evaluates whether a nanoemulsion form that improves absorption and enhances absorption and bioavailability might produce better results.
Eighty children between 3 and 6 years of age diagnosed with ASD were randomly assigned into two groups: one receiving the vitamin D3 nanoemulsion and the other a standard vitamin D3 product, both for a duration of 6 months. Their vitamin D3 levels, adaptive behavior, and language skills were assessed before and after supplementation using standardized tools such as the Autism Rating Scale for Children, Vineland Adaptive Behavior Scale, and Preschool Language. Only the nanoemulsion group showed statistically significant improvements in vitamin D3 levels, autism severity, social IQ, and receptive and expressive language performance. Conventional supplementation did not result in meaningful improvement in behavioral outcomes despite increasing blood vitamin D3 levels.
The study concludes that the nanoemulsion form of vitamin D3 is superior to the traditional oral form in increasing vitamin bioavailability and producing clinically relevant improvements in children with ASD. The authors suggest that nanoemulsion technology could provide a valuable strategy for improving the effectiveness of nutritional interventions in neurodevelopmental disorders. However, they acknowledge that further studies with larger sample sizes and long-term follow-up are needed to confirm these results and examine potential gender differences in response.
Sources:
Meguid, N.A.,et al. (2025). Improved core manifestations of autism following supplementation with vitamin D3-loaded nanoemulsion. LabMed Discovery. doi.org/10.1016/j.lmd.2025.100071.