To investigate the role of SNPs in the early diagnosis of coronary microvascular dysfunction

To investigate the role of SNPs in the early diagnosis of coronary microvascular dysfunction

A new review highlights the potential role of single nucleotide polymorphisms (SNPs) in improving early diagnosis and targeted intervention of coronary microvascular dysfunction (CMD) - a condition associated with myocardial ischemia.

TMD affects a significant proportion of patients with chest pain, particularly women, and is associated with a poor cardiovascular prognosis. However, current diagnostic approaches remain cumbersome and effective treatments are limited. The review examines how genetic markers, particularly SNPs, could aid risk prediction, disease prognosis and personalized therapy for CMD.

The study synthesizes existing findings on CMD-related SNPs and describes their effects on vascular function, inflammation and endothelial dysfunction. It also examines potential genetic links between TMD and other cardiovascular diseases such as coronary artery disease (CAD) and atherosclerosis, identifying common risk factors that could guide further research.

In particular, the review highlights the pathogenic mechanisms of CMD and emphasizes how SNPs can influence vasoconstriction, endothelial function and microvascular remodeling. In addition, the paper identifies SNPs associated with important risk factors such as diabetes, hypertension and hyperlipidemia, further expanding the scope of genetic insights in CMD.

The results suggest that a genetic approach could revolutionize TMD diagnosis and treatment, providing a path to precision medicine in cardiovascular health. Future research is expected to focus on validating these genetic markers and integrating them into clinical practice to improve patient outcomes.

This comprehensive review provides the foundation for advancing genetic research in CMD with implications for early detection and novel therapeutic strategies targeting microvascular dysfunction.

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